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  4. Recombinant Chicken Ephrin-A5 (EFNA5)

Recombinant Chicken Ephrin-A5 (EFNA5)

  • 货号：
    CSB-YP007464CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007464CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007464CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007464CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007464CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    EFNA5; RAGSEphrin-A5; EPH-related receptor tyrosine kinase ligand 7; LERK-7; Repulsive axon guidance signal protein
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    21-203
  • 氨基酸序列
    QEPGRKAVAD RYAVYWNSTN PRFQQGDYHI DVCINDYLDV FCPHYEDSVP EDKTERYVLY MVNFDGYSSC DHISKGFKRW ECNRPHSPNG PLKFSEKFQL FTPFSLGFEF RPGREYFYIS SAIPDNGRRS CLKLKVFVRP ANSCMKTIGV HDRVFDVNDK VENSLEPADD TVRESAEPSR GEN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. Induces growth cone collapse and repulsion of retinal ganglion cell axons.
  • 基因功能参考文献：
    1. EphA4-ephrin-A5 signaling acts in a positive manner to constrain axons in the medial portion of the medial motor column to the rostral half-sclerotome [ephrin-A5] PMID: 14762125
    2. Both soluble and membrane-attached ephrin-A5 inhibited growth of approximately half of each population of sensory axons in chick embryo. Ectopic expression of ephrin-A5 in ovo reduced arborization of cutaneous axons in skin on the limb PMID: 15949793
    3. Quantitative analysis of axon outgrowth shows that the stop reaction is controlled by a combination of the local ephrin concentration and the total amount of encountered ephrin. PMID: 16763203
    4. Our data suggest that growth factors and the EphA-ephrinA system interact in a way that affects axon branching and synapse development. PMID: 19036963
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Ephrin family
  • 组织特异性：
    Expressed in a graded fashion across the tectum being more strongly expressed towards the posterior pole.
  • 数据库链接：

    KEGG: gga:396100

    STRING: 9031.ENSGALP00000000368

    UniGene: Gga.19368