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  4. Recombinant Chicken Basic helix-loop-helix transcription factor scleraxis (SCX)

Recombinant Chicken Basic helix-loop-helix transcription factor scleraxis (SCX)

  • 货号：
    CSB-YP020869CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP020869CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP020869CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP020869CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP020869CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SCX
  • Uniprot No.：
  • 别名：
    SCX; Basic helix-loop-helix transcription factor scleraxis
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-187
  • 氨基酸序列
    MSFAMLRPAA GRYLYPEISM LSEDEENGSE SSGSDEKPFH LDADGFGIKA GKRRSGKKAG RLHREPRQRH TANARERDRT NSVNTAFTAL RTLIPTEPAD RKLSKIETLR LASSYISHLG NVLLVGEACG DGQPCHTSPA FFHHGGGGGS PPPRDSENSQ PKQICTFCLS NQRKLSKDRD RKTAIRS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.
  • 基因功能参考文献：
    1. Gain-of-function and loss-of-function experiments in the micromass culture assay revealed a positive transcriptional influence of Fhl2 in the expression of Scleraxis. PMID: 29330921
    2. Overexpression of Btg1 induced intense upregulation of Scleraxis. In complementary knockdown experiments, this marker was regulated in an opposite fashion. PMID: 26662056
    3. These studies identify an important role for Scx in regulating proteoglycans in embryonic and mature valve cells. PMID: 24157418
    4. TGF B treatments upregulate Scleraxis preceding both fibrogenesis in the micromass cultures and cartilage differentiation during interdigital ectopic chondrogenesis. PMID: 19717568
    5. The stage dependent transcriptional regulation of Scleraxis by BMPs is a finding relevant to understand BMP's function in connective tissue differentiation. PMID: 24038612
    6. More mature neurogenic progenitor cells express Sox2 and the bHLH transcription factor, E2A, and not Delta1 PMID: 19842182
    7. Transcriptional activation by Pea3 and Erm in response to FGF signaling is both necessary and sufficient for Scx expression. PMID: 15253939
    8. increased or decreased levels of phosphorylated ERK result in the loss of scleraxis transcripts, distal rib development PMID: 15716340
    9. These findings suggest that TeM is a late marker of tendon formation and that Scx positively regulates TeM expression in a tendon cell lineage-dependent manner. PMID: 16876153

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the intersomitic, the superficial proximomedial limb mesenchyme and the subectodermal mesenchyme.
  • 数据库链接：

    KEGG: gga:374101

    UniGene: Gga.49818