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  4. Recombinant Ceratogyrus marshalli Beta-theraphotoxin-Cm1b

Recombinant Ceratogyrus marshalli Beta-theraphotoxin-Cm1b

  • 货号：
    CSB-YP307481CGN
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP307481CGN
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP307481CGN-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP307481CGN
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP307481CGN
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    Beta-theraphotoxin-Cm1b; Beta-TRTX-Cm1b; CcoTx-II; Ceratotoxin-2; CcoTx2
  • 种属：
    Ceratogyrus marshalli (Straighthorned baboon tarantula) (Ceratogyrus cornuatus)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    1-33
  • 氨基酸序列
    DCLGWFKSCD PKNDKCCKNY TCSRRDRWCK YYL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits several voltage-gated sodium channels and only one voltage-gated calcium channel (Cav2.2/CACNA1B (IC(50)=1.1 uM) and Nav1.2/SCN2A (IC(50)=3.7-80 nM), Nav1.3/SCN3A (IC(50)=88-5570 nM), Nav1.1/SCN1A (IC(50)=170-407 nM), Nav1.7/SCN9A (IC(50)=95.5-230 nM), Nav1.6/SCN6A (IC(50)=49.9-3990 nM), Nav1.4/SCN4A (IC(50)=113-400 nM or >10 uM), Nav1.5/SCN5A (IC(50)=1524-1634 nM or >10 uM)). The toxin acts by shifting the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the sodium current. It shows moderate affinity for lipid bilayers without cholesterol and high affinity for lipid bilayers containing cholesterol. In vivo, this toxin causes general ataxia, lack of response to stimuli, and semiparalysis. After a few minutes, the mice are unable to stand, and breathing is reduced in rhythm and intensity. Symptoms gradually increase with progressive slowing of breathing and flaccid paralysis; death occurred within 10 to 20 minutes post injection. Animals remain totally flaccid, and no symptoms of excitatory neurotoxicity are observed.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Huwentoxin-1 family, CcoTx1 subfamily
  • 组织特异性：
    Expressed by the venom gland.