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  4. Recombinant Cat Proto-oncogene c-Fos (FOS)

Recombinant Cat Proto-oncogene c-Fos (FOS)

  • 货号：
    CSB-YP814168CA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP814168CA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP814168CA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP814168CA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP814168CA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FOS; Proto-oncogene c-Fos; Cellular oncogene fos
  • 种属：
    Felis catus (Cat) (Felis silvestris catus)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-381
  • 氨基酸序列
    MMFSGFNADY EASSSRCSSA SPAGDNLSYY HSPADSFSSM GSPVNAQDFC TDLAVSSANF IPTVTAISTS PDLQWLVQPT LVSSVAPSQT RAPHPYGVPA PSAGAYSRAG VVKTVTAGGR AQSIGRRGKV EQLSPEEEEK RRIRRERNKM AAAKCRNRRR ELTDTLQAET DQLEDEKSAL QTEIANLLKE KEKLEFILAA HRPACKIPDD LGFPEEMSVA SLDLSGGLPE AATPESEEAF TLPLLNDPEP KPSVEPVKSI SSMELKAEPF DDFLFPASSR PSGSETARSV PDMDLSGSFY AADWEPLHGG SLGMGPMATE LEPLCTPVVT CTPSCTTYTS SFVFTYPEAD SFPSCGAAHR KGSSSNEPSS DSLSSPTLLA L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
  • 基因功能参考文献：
    1. c-Fos-positive cells in the left spinal nucleus of the trigeminus, the bilateral insula, and the bilateral operculum increased. PMID: 24965534
    2. Expression of the immediate early gene c-Fos as a marker for neurons activated by stimulation of the otoliths or the semicircular canals engages brainstem structures both within and outside of the vestibular nuclear complex (VNC). PMID: 20570661
    3. In the retina injury, the intracellular down-regulation of Fos rather than a decline in the number of Fos-immunoreactive nuclei. Interestingly, the infragranular layers displayed more Fos-immunoreactive neurons in experimental animals. PMID: 20602093
    4. C-fos protein labeled cells in laminae VII, VIII, and X are premotor interneurons involved in the production of locomotion, whereas the laminae III and IV cells are those activated during locomotion due to afferent feedback from the moving limb PMID: 15634712
    5. The presence of c-jun and c-fos proteins in neurons and glial cells of normal cats indicates that they have ongoing physiological functions in the dorsal root ganglion and spinal cord. PMID: 16730915

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  • 亚细胞定位：
    Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol.
  • 蛋白家族：
    BZIP family, Fos subfamily
  • 数据库链接：

    KEGG: fca:493935

    STRING: 9685.ENSFCAP00000021643