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  4. Recombinant COP9 signalosome complex subunit 5 (csn-5)

Recombinant COP9 signalosome complex subunit 5 (csn-5)

  • 货号：
    CSB-YP005792CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005792CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005792CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005792CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005792CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    csn-5
  • Uniprot No.：
  • 别名：
    csn-5; B0547.1COP9 signalosome complex subunit 5; Signalosome subunit 5; EC 3.4.-.-; JAB1 homolog
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-368
  • 氨基酸序列
    MEVDNVKPSS SVPQRNWEKE NNVQNVDSIF EYNNKQQVEI RNAKPWDKDP HYFKQIKISA IALLKMTMHA KRGGNLEIMG LLQGRIDANS FIILDVFALP VEGTETRVNA QAQAYEYMTV YSEMCDTEGR KEKVVGWYHS HPGYGCWLSG IDVSTQTLNQ KFQEPWVAIV IDPLRTMSAG KVDIGAFRTY PEGYRPPDDV PSEYQSIPLA KIEDFGVHCK RYYSLDVSFF KSQLDAHILT SLWNSYWIST LSSSPLFSNV EFLNNQIQDI NQKLSAVDKK LQLNDRSVDG HEALMKVVTD AKAVGDELET GRISHLVKQL LFARQAGGGC GCSHASAGSP MDIAVATEPE KAGPSPSAPE PAVEMADA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3. May stabilize glh-1 protein levels by antagonizing kgb-1.
  • 基因功能参考文献：
    1. The work described here supports a previously unknown role for the CSN/COP9 signalosome in chromosome behavior during meiotic prophase I. PMID: 25375142
    2. Data show that CSN-5 functions in muscle cells to regulate UNC-98 and -96, two M-line proteins. PMID: 19535455
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase M67A family, CSN5 subfamily
  • 数据库链接：

    KEGG: cel:CELE_B0547.1

    STRING: 6239.B0547.1.1

    UniGene: Cel.13634