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  4. Recombinant Bovine Metalloproteinase inhibitor 1 (TIMP1)

Recombinant Bovine Metalloproteinase inhibitor 1 (TIMP1)

  • 货号：
    CSB-YP023560BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023560BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023560BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023560BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023560BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    TIMP1; Metalloproteinase inhibitor 1; Embryogenin-1; EG-1; Tissue inhibitor of metalloproteinases 1; TIMP-1
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-207
  • 氨基酸序列
    CTCVPPH PQTAFCNSDV VIRAKFVGTA EVNETALYQR YEIKMTKMFK GFSALRDAPD IRFIYTPAME SVCGYFHRSQ NRSEEFLIAG QLSNGHLHIT TCSFVAPWNS MSSAQRRGFT KTYAAGCEEC TVFPCSSIPC KLQSDTHCLW TDQLLTGSDK GFQSRHLACL PREPGLCTWQ SLRAQMA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.
  • 基因功能参考文献：
    1. Decreased MMP-9 and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle. PMID: 21328105
    2. We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF on MMP-9 and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography. PMID: 20578063
    3. Production of TIMP-1 was augmented by IL-1alpha, TNFalpha, and hepatocyte growth factor at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments. PMID: 12606436
    4. the different temporal expression patterns of TIMP-1 and TIMP-2 suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance PMID: 14613539
    5. Identification, purification and partial characterization of bovine pulmonary artery smooth muscle tissue inhibitor of matrix metalloproteinase-1 PMID: 14674693
    6. analysis of species specificity of human and bovine TIMP-1 binding to mouse TIMP-1 receptor PMID: 16019435

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I35 (TIMP) family
  • 数据库链接：

    KEGG: bta:282092

    STRING: 9913.ENSBTAP00000006653

    UniGene: Bt.27976