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  4. Recombinant Bovine Inhibin alpha chain (INHA)

Recombinant Bovine Inhibin alpha chain (INHA)

In Stock
  • 货号：
    CSB-EP011718BO
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    INHA
  • Uniprot No.：
  • 别名：
    INHA; Inhibin alpha chain
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    30.6kDa
  • 表达区域：
    227-360aa
  • 氨基酸序列
    STPPLPWPWSPAALRLLQRPPEEPAAHADCHRAALNISFQELGWDRWIVHPPSFIFYYCHGGCGLSPPQDLPLPVPGVPPTPVQPLSLVPGAQPCCAALPGTMRPLHVRTTSDGGYSFKYEMVPNLLTQHCACI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    Recombinant Bovine INHA protein is an E.coli-expressed protein (Full Length of Mature Protein). Molecularly, this INHA protein is characterized by N-terminal 6xHis-SUMO tag, internal Bovine INHA DNA fragment (227-360aa). Standard methods for recombinant INHA protein expression comprise transfecting cells with DNA vectors that consist of specific templates and then cultures cells to translate and transcribe the INHA protein production process. Typically, these cells are lysed to extract expressed proteins for more purification. The purity of this recombinant INHA protein is 90%+ measured by SDS-PAGE.

    INHA is the alpha subunit of inhibin, the inhibitor of the synthesis and secretion of pituitary gonadotropins, especially follicle-stimulating hormone (FSH). INHA has recently been involved in prostate tumorigenesis. It is overexpressed in mice, leading to aberrant reproductive function, including reduced litter and embryo size. INHA expression was declined in early-stage tumors but elevated in late-stage, metastatic prostate malignancies, implying that inhibins function as tumor inhibitors in the early stage of carcinogenesis but may serve as tumor promoters during late-stage disease.

     

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
  • 基因功能参考文献：
    1. The effects of castration and other surgical intervention on the blood levels of anti-Muellerian hormone, inhibin A, gonadotropins, and gonadotropin receptors in bull calves are reported. PMID: 27693012
    2. The expression of the components of the activin-inhibin-follistatin system is altered in bovine cystic ovarian disease. PMID: 25001504
    3. INHA gene can be used as a predictor for superovulation in Chinese Holstein cows. PMID: 20238172
    4. Inhibin has a negative autocrine or paracrine effect on the in vitro capacity of granulosa cells isolated from dominant or subordinate follicles to produce estradiol. PMID: 12697695
    5. overexpression of inhibin alpha (1-32) fragment regulated granulosa cell development and effects on subsequent oocyte maturation were both time- and stage-dependent PMID: 18456314

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 数据库链接：

    KEGG: bta:281254

    STRING: 9913.ENSBTAP00000013154

    UniGene: Bt.36723