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  4. Recombinant Bovine Cyclic AMP-responsive element-binding protein 1 (CREB1)

Recombinant Bovine Cyclic AMP-responsive element-binding protein 1 (CREB1)

  • 货号：
    CSB-YP005947BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005947BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005947BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005947BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005947BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CREB1; CREB; CREB2Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1; Cyclic AMP-responsive DNA-binding protein
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-325
  • 氨基酸序列
    MESGAENQQS GDAAVTEAES QQMTVQAQPQ IATLAQVSMP AAHATSSAPT VTLVQLPNGQ TVQVHGVIQA AQPSVIQSPQ VQTVQISTIA ESEDSQESVD SVTDSQKRRE ILSRRPSYRK ILNDLSSDAP GVPRIEEEKS EEETSAPAIT TVTVPTPIYQ TSSGQYIAIT QGGAIQLANN GTDGVQGLQT LTMTNAAATQ PGTTILQYAQ TTDGQQILVP SNQVVVQAAS GDVQTYQIRT APTSTIAPGV VMASSPALPT QPAEEAARKR EVRLMKNREA ARECRRKKKE YVKCLENRVA VLENQNKTLI EELKALKDLY CHKSD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
  • 基因功能参考文献：
    1. Data indicate that Ser738/742-to-glutamate protein kinase D mutant increased AngII-induced CREB protein and activating transcription factor 2 phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein promoter. PMID: 24708239
    2. SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia. PMID: 12552083
    3. dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 PMID: 12810819
    4. the p38-MAPK/CREB pathway plays a critical role in TNFalpha-induced VCAM-1 expression PMID: 16715652
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family
  • 数据库链接：

    KEGG: bta:281713

    STRING: 9913.ENSBTAP00000007201

    UniGene: Bt.4183