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  4. Recombinant Bovine Bone morphogenetic protein 15 (BMP15)

Recombinant Bovine Bone morphogenetic protein 15 (BMP15)

  • 货号：
    CSB-YP002735BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002735BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002735BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002735BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002735BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BMP15
  • Uniprot No.：
  • 别名：
    BMP15Bone morphogenetic protein 15; BMP-15
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    270-394
  • 氨基酸序列
    Q AGSIASEVPG PSREHDGPES NLCSLHPFQV SFQQLGWDHW IIAPHLYTPN YCKGVCPRVL HYGLNSPNHA IIQNLVNELV DQSVPQPSCV PYKYVPISIL LIEANGSILY KEYEGMIAQS CTCR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
  • 基因功能参考文献：
    1. This study concluded that the improved pregnancy rate after porcine LH-induced ovulation reported previously occurred through greater activation of intrafollicular transforming growth factor-beta1 superfamily members, as these proteins promote cumulus expansion and oocyte competence. PMID: 26794084
    2. Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence. PMID: 24557840
    3. In conclusion, BMP-15 should be considered as a potential genetic marker for sperm quality, based on its association with fresh sperm motility. PMID: 24668668
    4. BMP15 and FGF10 stimulate expansion of in cumulus-oocyte complexes by driving glucose metabolism toward hyaluronic acid production and controlling gene expression in the ovulatory cascade. PMID: 23641036
    5. Immunization against GDF9 and BMP15, alone or together, altered follicular development and ovulation rate in cattle. PMID: 19439562
    6. BMP15 expression in the oocytes of calf and adult ovaries was not significantly different. BMP15 transcripts were detected in ovarian tissues, but were not detected in any other tissues examined by RT-PCR. PMID: 21401961
    7. Maternal BMP15 transcripts persisted during oocyte in vitro maturation and fertilization and in preimplantation embryo until the five- to eight-cell or morula stage, but transcription was not reactivated at the time of embryonic genome activation. PMID: 15189828
    8. polymorphism in the bovine bone morphogenetic protein 15 (BMP15) gene PMID: 19433911

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 数据库链接：

    KEGG: bta:353351

    STRING: 9913.ENSBTAP00000056137

    UniGene: Bt.22954