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  4. Recombinant Bothrops jararaca Bradykinin-potentiating and C-type natriuretic peptides

Recombinant Bothrops jararaca Bradykinin-potentiating and C-type natriuretic peptides

  • 中文名称：
    Recombinant Bothrops jararaca Bradykinin-potentiating and C-type natriuretic peptides,Yeast
  • 货号：
    CSB-YP747030BUW
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bothrops jararaca Bradykinin-potentiating and C-type natriuretic peptides,Yeast
  • 货号：
    CSB-EP747030BUW
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Bothrops jararaca Bradykinin-potentiating and C-type natriuretic peptides,Yeast
  • 货号：
    CSB-EP747030BUW-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bothrops jararaca Bradykinin-potentiating and C-type natriuretic peptides,Yeast
  • 货号：
    CSB-BP747030BUW
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bothrops jararaca Bradykinin-potentiating and C-type natriuretic peptides,Yeast
  • 货号：
    CSB-MP747030BUW
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    Bradykinin-potentiating and C-type natriuretic peptides; BPP-CNP) [Cleaved into: Bradykinin-potentiating peptide 6a; BPP-6a); Bradykinin-potentiating peptide 10a; BPP-10a; Bradykinin-potentiating peptide IV-1-A; BPPIV-1-A; Bradykinin-potentiating peptide V-8); Bradykinin-potentiating peptide 13a+QQWA; BPP-13a+QQWA); Bradykinin-potentiating peptide 13a+QWA; BPP-13a+QWA); Bradykinin-potentiating peptide 13a; BPP-13a; Bradykinin-potentiating peptide III-1-A; III-1-A; Bradykinin-potentiating peptide V-9); Bradykinin-potentiating peptide 10c+QQWA; BPP-10c+QQWA); Bradykinin-potentiating peptide 10c; BPP-10c; BPP-2; Bradykinin-potentiating peptide IV-1-Bbeta; BPP IV-1-Bbeta; Bradykinin-potentiating peptide V-7); Bradykinin-potentiating peptide 10c-F; BPP-10c-F); Bradykinin-potentiating peptide 11b; BPP-11b; Bradykinin-potentiating peptide IIa; BPP-IIa); Bradykinin-potentiating peptide IIb; BPP-IIb); Bradykinin-potentiating peptide 5a; BPP-5a; Bradykinin-potentiating peptide Va; BPPVa; Proline-rich peptide 5a; Bj-PRO-5a; PRO-5a); Poly-His-poly-Gly peptide 1; pHpG-1); C-type natriuretic peptide; Bj-CNP)]
  • 种属：
    Bothrops jararaca (Jararaca)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    31-40
  • 氨基酸序列
    QSWPGPNIPP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    modestly inhibits ACE (with highest affinity for the N-site) and reveals strong bradykinin-potentiating activity. Induces nitric oxide (NO) production depended on muscarinic acetylcholine receptor M1 subtype (CHRM1) and bradykinin B2 receptor (BDKRB2) activation. Both these receptors contribute to the vasodilation induced by this peptide that may have an indirect action on BDKRB2 and a direct agonistic action on CHRM1.; peptide with several activities. It inhibits the activity of the angiotensin-converting enzyme (ACE) by a preferential interaction with its C-domain. It evokes transient hypotension (-14 mmHg) similar to that evoked by 0,5 ug of bradykinin, when injected alone into rats. It has a high bradykinin-potentiating effect (120%), when 60 nmol of BPP-10c are coinjected with 0.5 ug of bradykinin into rats. Does not affect angiotensin-1 pressor effects. Shows potent and long-lasting antihypertensive activity as well as a reduction of the heart rate. It also binds and dose-dependently promotes the activation of cytosolic argininosuccinate synthase (ASS1), an enzyme that catalyzes the conversion of citrulline, L-aspartate and ATP to argininosuccinate, AMP and pyrophosphate. It also enhances ASS1-dependent arginine production in HEK 293 cells, as well as in spontaneous hypertensive rat (SHR) and Wistar rat plasma. In addition, it induces the production of nitric-oxide (NO) by HUVEC cells via the endothelial nitric-oxide synthase (NOS3), which use arginine as a substrate and produce NO. It has been shown to be internalized by ASS1-expressing endothelial (HUVEC) and kidney (HEK 293) cells, and is detected homogenously distributed within the cell cytoplasm for up to 2 hours.; has much lower activity than the full-length bradykinin-potentiating peptides.; may serve as a metalloproteinase inhibitor during glandular storage. Their inhibition may be instantly disengaged, by dilution or physiochemical change, when venom is injected into tissue of the victim.; Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity. Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3).
  • 亚细胞定位：
    Secreted. Cytoplasm, cytosol. Note=BPP-10c is internalized in the cytosol of prey cells.
  • 蛋白家族：
    Bradykinin-potentiating peptide family; PHpG family; Natriuretic peptide family
  • 组织特异性：
    Expressed in venom gland.