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  4. Recombinant ADAM family mig-17 (mig-17)

Recombinant ADAM family mig-17 (mig-17)

  • 货号：
    CSB-YP631334CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP631334CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP631334CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP631334CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP631334CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    mig-17
  • Uniprot No.：
  • 别名：
    mig-17; F57B7.4; Metalloprotease mig-17; EC 3.4.24.-; Abnormal cell migration protein 17
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-509
  • 氨基酸序列
    ARREKQQSND ISFVKRKVQD GLKFSRVIKY TNETIQGMKT NFNSNKTQEL SLDVLVVADF LSYQAFLEMS NGDSHRAIHN LKEYLHALFE QTKIIYDGIS FGNETLHMVF AGTWIATQER DCPLWISWAE EEEERVLNEE IRRLEEKERD LNSTFVDDTF FMNSTDSDNS STDALISSDM PKKLRKFVDI TLEEMQENNS TEMTLKIDSK KAIDKFTIWL KEQTGLPRHE HAVLITKFDL ISINGNSATQ GMAYVGNICE NGDSSSVVED IGAGLTSLIM AHEIGHSLGA LHDGAYETAE CDSNDNYLMA VAVSGSADRQ SFLNSRRMSN CSINSIIENL KEPTANCVKK WKTKKGKDVS QKDFIKKPGE LVKITRQCQV AFGPTFIPCL HIGYFHEQSI CERIWCSDGE SDECQTLNYF PAFDGTECGY NMWCLEGSCV QNTKKWMDCK DINSKTCSKY STSKLKHYCK SKDFREICCR TCAKKGKIY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does not recruit fbl-1 to the pharynx basement membrane.
  • 基因功能参考文献：
    1. It plays a role in cell migration in C. elegans. (review) PMID: 21077329
    2. Prodomain-dependent tissue targeting of MIG-17, an ADAMTS protease, controls cell migration in Caenorhabditis elegans. PMID: 17491590
    3. activation of MIG-17 is regulated in a spatiotemporal manner during C. elegans development. This is the first report demonstrating the regulated activation of an ADAMTS protein in vivo PMID: 18637819
    4. FBL-1C and LET-2 act downstream of MIG-17-dependent proteolysis to recruit NID-1 and that LET-2 also activates a NID-1-independent pathway, thereby inducing the remodeling of the BM required for directional control of leader cell migration. PMID: 19104038
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 组织特异性：
    Secreted from muscle cells and functions in the basement membrane of the gonad to guide DTC migration. Localizes to the pharyngeal basement membrane.
  • 数据库链接：

    KEGG: cel:CELE_F57B7.4

    STRING: 6239.F57B7.4

    UniGene: Cel.19490