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UAP1 Recombinant Monoclonal Antibody

  • 货号：
    CSB-RA174034A0HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: UAP1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 59, 58, 59 kDa
      Observed band size: 59 kDa
  • 其他：

产品详情

  • 产品描述：

    UAP1 catalyzes the last step in the eukaryotic biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), converting UTP and GlcNAc-1P to the sugar nucleotide. Previous studies showed that the abnormal expression of UAP1 was closely related to the biological processes of cancer cells. UAP1 is highly overexpressed in prostate cancer cells and protects cancer cells from endoplasmic reticulum stress to promote their development.

    The production of this recombinant UAP1 antibody started with identifying and cloning the genes for antibody expression. After the UAP1 antibody was cloned into an expression plasmid, the plasmid could be introduced into the mammalian cell to produce the target recombinant antibody. This recombinant UAP1 antibody has been validated in ELISA, WB.

  • Uniprot No.：
    Q16222
  • 基因名：
    UAP1
  • 别名：
    UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1), UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)], UAP1, SPAG2
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human UAP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    1F2
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
  • 基因功能参考文献：
    1. Results identified an enzyme, UAP1, which is highly overexpressed in prostate cancer and protects cancer cells from endoplasmic reticulum stress conferring a growth advantage. PMID: 25241896
  • 亚细胞定位：
    Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.
  • 蛋白家族：
    UDPGP type 1 family
  • 组织特异性：
    Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver.
  • 数据库链接：

    HGNC: 12457

    OMIM: 602862

    KEGG: hsa:6675

    STRING: 9606.ENSP00000356903

    UniGene: Hs.492859