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  4. RIOX2 Recombinant Monoclonal Antibody

RIOX2 Recombinant Monoclonal Antibody

  • 货号：
    CSB-RA810267A0HU
  • 规格：
    ￥1320
  • 其他：

产品详情

  • 产品描述：

    The recombinant RIOX2 antibody is a monoclonal antibody made in vitro using the RIOX2 antibody genes that are typically expressed from a plasmid in a stable mammalian cell line. The genes coding for the RIOX2 antibody will ultimately assemble into a fully functional antibody after translation. The synthesized antibody is the recombinant antibody against RIOX2. It underwent purification using affinity-chromatography. This recombinant RIOX2 antibody is suitable for use in the ELISA to detect the RIOX2 protein from Human.

    RIOX2, a JmjC (Jumonji-C) domain-containing 2-oxoglutarate (2OG)-dependent oxygenase, is implicated in gene transcription in eukaryotic cells. It promotes cell proliferation, cycle transition, and anti-apoptosis carcinogenic activities. RIOX2 upregulation has been found in several human solid and hematological malignancies, including colon, esophagus, lung, lymphocyte, kidney, nervous system, liver, breast, pancreas, and gastric cancers. Enhanced RIOX2 expression has been associated with a poor prognosis, and evidence has shown that RIOX2 downregulation inhibits cancer cell growth and survival.

  • Uniprot No.：
    Q8IUF8
  • 基因名：
    RIOX2
  • 别名：
    60S ribosomal protein L27a histidine hydroxylase antibody; Bifunctional lysine specific demethylase and histidyl hydroxylase MINA antibody; FLJ14393 antibody; Histone lysine demethylase MINA antibody; MDIG antibody; MINA antibody; MINA_HUMAN antibody; Mineral dust-induced gene protein antibody; Myc induced nuclear antigen 53 kDa antibody; MYC induced nuclear antigen antibody; MYC-induced nuclear antigen antibody; NO52 antibody; Nucleolar protein 52 antibody; Ribosomal oxygenase MINA antibody; ROX antibody
  • 反应种属：
    Human
  • 免疫原：
    A synthesized peptide derived from human RIOX2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    Rabbit IgG
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    1E8
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
  • 基因功能参考文献：
    1. RIOX2 transcripts were overexpressed in renal cell tumor subtypes compared to renal normal tissues. Higher RIOX2 transcript levels were associated with metastasis. PMID: 29099276
    2. our findings revealed that Mina53 was an important indicator of prognosis in patients with stage III colorectal cancer treated with adjuvant chemotherapy. PMID: 29750310
    3. Results indicate that mdig can inhibit the phosphorylation of GSK-3beta and promote the phosphorylation and destabilization of beta-catenin, in order to suppress the expression of slug, snail, and ZEB1 and the occurrence of EMT, and thereby inhibit the invasion and metastasis of non-small cell lung cancer (NSCLC). PMID: 29039479
    4. mdig directly interacts with c-myc and JAK1 in multiple myeloma (MM) cell lines, which contributes to hyperactivation of the IL-6-JAK-STAT3 signaling important for the pathogenesis of MM. PMID: 27833099
    5. MDIG overexpression substantially promoted hepatocellular carcinoma cell proliferation, cell migration and spreading, whereas knockdown of MDIG would reverse above-mentioned effect. PMID: 28471446
    6. Findings reveal the role of MINA in glioblastoma initiation and progression by controlling the cell-cycle progression through transcriptionally regulating cyclin and CDK expression via the demethylation of H3K9me3. PMID: 27292258
    7. Data suggest that mineral dust-induced gene protein (mdig) accomplishes its functions on chromatin, DNA repair and cell growth through interacting with the partner proteins. PMID: 26293673
    8. in lung cancer tissues, upregulation of mdig expression accompanies with the downregulation of p27(KIP1) expression and in bronchial stump PMID: 25851349
    9. Mina53 can be used as a marker for pancreatic cancer PMID: 24522517
    10. Mina: a Th2 response regulator meets TGFbeta. PMID: 25282476
    11. Increased expression of mdig in cancer tissues. PMID: 24505346
    12. mina53 expression was gradually elevated during gastric carcinogenesis, and the overexpression of mina53 was correlated with different clinicopathological features between diffuse-type gastric carcinoma and intestinal-type gastric carcinoma cases. PMID: 24337011
    13. Results imply that mdig is involved in the regulation of H3K9me3 to influence the heterochromatin structure of the genome and the expression of genes important for cell growth or transformation. PMID: 23965803
    14. results show mdig induction by arsenic is partially dependent on the JNK and STAT3 signaling pathways. PMID: 24434654
    15. these data suggest that an increased expression of mdig is an important prognostic factor for poorer survival time of the breast cancer patients. PMID: 24309373
    16. The single nucleotide polymorphism of the Mina gene is associated with the development of asthma in Chinese Han children. PMID: 21631300
    17. favorable prognostic marker in early stage lung cancer PMID: 19914733
    18. Mina53 plays an important role in carcinogenesis and may be a target for cancer prevention. PMID: 19756735
    19. role in cell division PMID: 12091391
    20. the elevated expression of Mina53 is a characteristic feature in colon cancer PMID: 14695334
    21. Mina53 may have a role in progression of esophageal squamous cell carcinoma PMID: 15534111
    22. Data suggests NO52 protein (MYC induced nuclear antigen) is directly involved in ribosome biogenesis, most likely during the assembly process of preribosomal particles. PMID: 15819408
    23. The expression of mineral dust induced mRNA was detected in alveolar macrophages from coal miners but not from normal subjects. PMID: 15897898
    24. Increased expression of Mina53 is associated with lymphoma PMID: 17786344
    25. Mina53 is overexpressed in renal cell carcinoma tissue from patients with poor prognostic factors, suggesting that Mina53 overexpression is one of the factors for poor prognosis in renal cell carcinoma. PMID: 17803656
    26. Mina53 was overexpressed in gastric carcinoma and associated with tumor proliferation and antioncogene inactivation. PMID: 18629780
    27. The MINA protein alters histone H3 methylation contributes to the initiation or development of the human lung cancer. PMID: 19502796

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  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族：
    ROX family, MINA53 subfamily
  • 组织特异性：
    Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal
  • 数据库链接：

    HGNC: 19441

    OMIM: 612049

    KEGG: hsa:84864

    STRING: 9606.ENSP00000328251

    UniGene: Hs.570562