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VTA1 Antibody

  • 货号：
    CSB-PA025940GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NP79
  • 基因名：
  • 别名：
    C6orf55 antibody; Chromosome 6 open reading frame 55 antibody; Dopamine responsive protein DRG 1 antibody; Dopamine-responsive gene 1 protein antibody; DRG 1 antibody; DRG-1 antibody; DRG1 antibody; Homolog of mouse SKD1 binding protein 1 antibody; HSPC228 antibody; LIP5 antibody; LYST interacting protein 5 antibody; LYST-interacting protein 5 antibody; My012 antibody; SBP1 antibody; SKD1 binding protein 1 antibody; SKD1-binding protein 1 antibody; Vacuolar protein sorting-associated protein VTA1 homolog antibody; Vps20 associated 1 homolog (S. cerevisiae) antibody; VTA1 antibody; VTA1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human VTA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR. Involved in HIV-1 budding.
  • 基因功能参考文献：
    1. Data suggest that AQP2 binds LIP5 in a AQP2-phosphorylation-dependent manner; phospho-mimicking mutations and phosphorylation reduce thermal stability of AQP2; AQP2 phosphorylation allosterically controls its interaction with LIP5. [AQP2 = aquaporin 2; LIP5 = LYST-interacting protein 5; LYST = lysosomal trafficking regulator protein] PMID: 28710278
    2. Crystal structures of three molecular complexes reveal that IST1 binds to the MIT domains of VPS4 and LIP5. PMID: 25657007
    3. the tandem MIT domain of LIP5 binds different types of ESCRT-III proteins, promoting assembly of active VPS4 enzymes on the polymeric ESCRT-III substrate. PMID: 23105106
    4. LIP5 protein expression in a mouse tissue panel and various rodent and human tissues were studied. PMID: 20358264
  • 亚细胞定位：
    Cytoplasm. Endosome membrane; Peripheral membrane protein.
  • 蛋白家族：
    VTA1 family
  • 数据库链接：

    HGNC: 20954

    OMIM: 610902

    KEGG: hsa:51534

    STRING: 9606.ENSP00000356602

    UniGene: Hs.431367