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VPS37A Antibody

  • 货号：
    CSB-PA256766
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA256766(VPS37A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA256766(VPS37A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human bladder carcinoma and fetal liver tissue, Primary antibody: CSB-PA256766(VPS37A Antibody) at dilution 1/300 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q8NEZ2
  • 基因名：
  • 别名：
    VPS37A antibody; HCRP1 antibody; Vacuolar protein sorting-associated protein 37A antibody; hVps37A antibody; ESCRT-I complex subunit VPS37A antibody; Hepatocellular carcinoma-related protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human VPS37A
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
  • 基因功能参考文献：
    1. HCRP1 is a negative regulator in prostate cancer progression, metastasis and multi-drug resistance. PMID: 28458158
    2. this study identifies HCRP1 downregulation correlates with tumor stage, nodal metastasis, and poor patient survival in human gastric cancer PMID: 28963677
    3. The present data indicate that HCRP1 inhibits breast cancer metastasis through downregulating EGFR phosphorylation. PMID: 27311861
    4. Low HCRP1 expression was found to be of adverse prognostic significance in patients with oral and oropharyngeal squamous cell carcinoma who received preoperative chemoradiotherapy PMID: 22891969
    5. The missense mutation c.1146A>T in Vps37A causes autosomal recessive complex hereditary spastic paraparesis. PMID: 22717650
    6. Data show hVps37A mRNA downregulation in ovarian cancer. PMID: 22016507
    7. Our results strongly suggest that HCRP1 might be a growth inhibitory protein and associated with decreasing the invasion of HCC cells PMID: 14623289
    8. HCRP1 is a subunit of mammalian ESCRT-I, and its function is essential for lysosomal sorting of EGF receptors. PMID: 15240819

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  • 相关疾病：
    Spastic paraplegia 53, autosomal recessive (SPG53)
  • 亚细胞定位：
    Late endosome membrane; Peripheral membrane protein. Nucleus.
  • 蛋白家族：
    VPS37 family
  • 组织特异性：
    Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas.
  • 数据库链接：

    HGNC: 24928

    OMIM: 609927

    KEGG: hsa:137492

    STRING: 9606.ENSP00000318629

    UniGene: Hs.343873