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UST Antibody

  • 货号：
    CSB-PA897525LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA897525LA01HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UST Polyclonal antibody
  • Uniprot No.：
    Q9Y2C2
  • 基因名：
    UST
  • 别名：
    2OST antibody; DS2ST antibody; Uronyl 2-sulfotransferase antibody; uronyl-2-sulfotransferase antibody; Ust antibody; UST_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Uronyl 2-sulfotransferase protein (85-183AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，UST Antibody (CSB-PA897525LA01HU)，的标记方式是Non-conjugated。对于UST Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA897525LB01HU UST Antibody, HRP conjugated ELISA
    FITC CSB-PA897525LC01HU UST Antibody, FITC conjugated
    Biotin CSB-PA897525LD01HU UST Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.
  • 基因功能参考文献：
    1. Results show that overexpression of 2OST alone in the HEK293 cells did not appreciably affect heparan sulfate (HS) chain length. Also, its simultaneous overexpression with Hsepi abolished the effect of Hsepi overexpression on the HS chain lengh. PMID: 27511124
    2. Statistical analysis showed the strongest evidence for a variant located in an intron of UST associated with job-related exhaustion. PMID: 23620144
    3. 2OST transfers sulfate preferentially to the GlcA residue located in a unique sequence, -GalNAc(4SO(4))-GlcA-GalNAc(6SO(4))-. PMID: 16192264
    4. analysis of differences and similarities various residues play in the biological roles of the HS-2OST and CS-2OST enzymes PMID: 17227754
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Sulfotransferase 3 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 17223

    OMIM: 610752

    KEGG: hsa:10090

    STRING: 9606.ENSP00000356433

    UniGene: Hs.657370