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USP30 Antibody

  • 货号：
    CSB-PA067099
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HeLa cells, using USP30 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) USP30 Polyclonal antibody
  • Uniprot No.：
    Q70CQ3
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human USP30.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
  • 基因功能参考文献：
    1. the role of USP30 in the dynamic networks of mitochondrial quality control and its physiological implications. PMID: 29178074
    2. Here the s report crystal structures of human USP30 bound to monoubiquitin and Lys6-linked diubiquitin, which explain how USP30 achieves Lys6-linkage preference through unique ubiquitin binding interfaces. PMID: 28945249
    3. show that USP30 delays mitophagy by delaying PARK2 recruitment to the mitochondria during mitophagy PMID: 25915564
    4. These results provide the first evidence for a fundamental role of USP30 in determining the threshold for mitochondrial cell death and suggest USP30 as a potential target for combinatorial anti-cancer therapy. PMID: 25739811
    5. The mechanism by which parkin, an E3 ubiquitin ligase, and USP30, a mitochondrion-localized deubiquitylase, regulate mitophagy, was investigated. PMID: 25621951
    6. reducing USP30 activity enhances mitochondrial degradation in neurons PMID: 24896179
    7. USP30 participates in the maintenance of mitochondrial morphology, a finding that provides new insight into the cellular function of deubiquitination. PMID: 18287522

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  • 亚细胞定位：
    Mitochondrion outer membrane.
  • 蛋白家族：
    Peptidase C19 family
  • 组织特异性：
    Expressed in skeletal muscle, pancreas, liver and kidney.
  • 数据库链接：

    HGNC: 20065

    OMIM: 612492

    KEGG: hsa:84749

    STRING: 9606.ENSP00000257548

    UniGene: Hs.486434