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UPK3A Antibody

  • 货号：
    CSB-PA025657ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA025657ESR2HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA025657ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UPK3A Polyclonal antibody
  • Uniprot No.：
    O75631
  • 基因名：
    UPK3A
  • 别名：
    UPK3A; UPK3; Uroplakin-3a; UP3a; Uroplakin III; UPIII
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Uroplakin-3a protein (19-207AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
  • 基因功能参考文献：
    1. High expression level of preoperative serum Uroplakin III is associated with biologically aggressive bladder cancer. PMID: 25743828
    2. High Uroplakin III expression is associated with bladder urothelial carcinoma from malignancy metastatic to the urinary bladder. PMID: 25368291
    3. a strong association between UPIII and in the group with tumor recurrence PMID: 24553301
    4. Loss of p63 expression is a prerequisite for uroplakin III expression in urothelial bladder cancer. PMID: 14654529
    5. Our results indicate that de novo mutations in UPIIIA can be involved in defective early kidney development, but probably constitute only a rare cause of human renal hypodysplasia in a minor subset of individuals [UPIIIA]. PMID: 16731295
    6. uroplakin III and III-delta4 genes were significantly up-regulated only in patients with nonulcerative interstitial cystitis PMID: 17698128
    7. Uroplakin III mRNA is up-regulated to a greater extent in vesicoureteral reflux than in control exfoliated urinary cells. PMID: 17880289
    8. Loss of UP III expression is associated with established markers of biologically aggressive bladder cancer PMID: 18313120
    9. Not a useful immunohistochemical marker for detection of pleural malignant mesothelioma. PMID: 18528285
    10. Uroplakin III plays a pivotal role in Eshcerichia coli UTI pathogenesis. PMID: 19007907
    11. studies suggest that bacteria-induced UPIIIa signaling is a critical mediator of bladder responses to insult by uropathogenic E. coli PMID: 19412341

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  • 相关疾病：
    Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Uroplakin-3 family
  • 组织特异性：
    Expressed in ureter.
  • 数据库链接：

    HGNC: 12580

    OMIM: 611559

    KEGG: hsa:7380

    STRING: 9606.ENSP00000216211

    UniGene: Hs.632787