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UMODL1 Antibody

  • 货号：
    CSB-PA025617LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: NIH/3T3 whole cell lysate, MCF-7 whole cell lysate
      All lanes: UMODL1 antibody at 5.1µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 145, 157, 137, 150 kDa
      Observed band size: 145, 157 kDa
    • IHC image of CSB-PA025617LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA025617LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of MCF-7 cells with CSB-PA025617LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品描述：

    This antibody reacts against the human and mouse UMOLD1 protein. It was raised in rabbit using the partial human UMOLD1 protein as the immunogen. The immunogen region corresponds to the 537-654aa of Recombinant Human UMOLD1 that is a section of the second EGF-like domain. This antibody is a non-conjugate polyclonal IgG with a purity higher than 95% purified by protein G. The uses of this antibody were tested on ELISA, Western blot (WB), Immunohistochemistry (IHC), and Immunofluorescence (IF) applications. The target protein UMOLD1 participates in the response of gonadotropin-releasing hormone, regulates gene expression, and with that, the adipose tissue and ovarian follicle development. The domains of the protein are suggested to bind calcium, interact with proteins, carbohydrate side chains, and other types of substrates. Also, UMOLD1 could have an antiproteinase function, and the presence of the zona pellucida domain (ZP) suggests that the UMOLD1 could have fundamental roles in development, hearing, immunity, or cancer. Indeed, some evidence suggests that it plays a role in high myopia susceptibility.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UMODL1 Polyclonal antibody
  • Uniprot No.：
    Q5DID0
  • 基因名：
    UMODL1
  • 别名：
    D17Ertd488e antibody; Olfactorin antibody; OTTHUMP00000109312 antibody; OTTHUMP00000109313 antibody; RGD1566039 antibody; UMODL1 antibody; UROL1_HUMAN antibody; Uromodulin-like 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Uromodulin-like 1 protein (537-654AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，UMODL1 Antibody (CSB-PA025617LA01HU)，的标记方式是Non-conjugated。对于UMODL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA025617LB01HU UMODL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA025617LC01HU UMODL1 Antibody, FITC conjugated
    Biotin CSB-PA025617LD01HU UMODL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. It was shown that common UMODL1 polymorphisms are unlikely to be important in the genetic susceptibility to high myopia in Han Chinese. PMID: 22857148
    2. Data report the isolation of a novel gene, designated UMODL1, similar to uromodulin (UMOD)/Tamm-Horsfall glycoprotein, on human chromosome 21q22.3. PMID: 15194491
    3. result suggests that rs283971 is located in the frequent recombinant region on the UMODL1, and that this region might play a critical role in disease susceptibility to high myopia. PMID: 18535602
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm.
  • 组织特异性：
    Isoform 4 is expressed at low level in kidney, testis and fetal thymus. Isoform 3 is expressed at low level in prostate, testis and fetal thymus.
  • 数据库链接：

    HGNC: 12560

    OMIM: 613859

    KEGG: hsa:89766

    UniGene: Hs.242520