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UGT8 Antibody

  • 货号：
    CSB-PA025602GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q16880
  • 基因名：
    UGT8
  • 别名：
    UGT8; CGT; UGT4; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human UGT8
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides.
  • 基因功能参考文献：
    1. An increase in the immunolabelling of ceramide was observed in cells where UDP glycosyltransferase 8 (UGT8) was down-regulated as opposed to cells where UGT8 was either not regulated or was up-regulated. PMID: 28746357
    2. Data indicate that ceramide galactosyltransferase (UGT8), although enhanced in non-small cell lung carcinoma (NSCLC) tissues, does not meet the criteria of a lung tumor marker. PMID: 27620310
    3. Our study suggests that CGT expression is controlled by balanced expression of the negative modulator OLIG2 and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners. PMID: 24821492
    4. A new role was identified for UGT8 as a modulator of bile acid homeostasis. PMID: 25519837
    5. High expression of UGT8 accompanied by accumulation of GalCer in MDA-MB-231 cells is associated with a much higher proliferative index and a lower number of apoptotic cells in comparison to the MDA/LUC-shUGT8 cells. PMID: 24391908
    6. Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population. PMID: 23118445
    7. UGT8 is a significant index of tumour aggressiveness and is seen in lung metastases of breast cancer. PMID: 20648017
    8. Single-nucleotide polymorphisms (SNPs) were found in UGT8 gene PMID: 12376738
    9. the GC-box and CRE function cooperatively, and that the CRE regulates the cell-specific expression of the hCGT gene PMID: 15229398
    10. We postulate that molecular link between defective GALT enzyme, which result in classic galactosemia and the cerebroside galactosyl transferase, responsible for galactosylation of cerebrosides, is dependent on concentrations of UDP-galactose. PMID: 16125333
    11. Gene expression of galactosyl ceramide synthase associated with poor pathohistological grading in breast cancer PMID: 19125296

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  • 亚细胞定位：
    Membrane; Single-pass membrane protein. Endoplasmic reticulum.
  • 蛋白家族：
    UDP-glycosyltransferase family
  • 数据库链接：

    HGNC: 12555

    OMIM: 601291

    KEGG: hsa:7368

    STRING: 9606.ENSP00000311648

    UniGene: Hs.144197