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TSPEAR Antibody

  • 货号：
    CSB-PA848817LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Raji whole cell lysate
      All lanes: TSPEAR antibody at 3.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 75, 67 kDa
      Observed band size: 75 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TSPEAR Polyclonal antibody
  • Uniprot No.：
    Q8WU66
  • 基因名：
    TSPEAR
  • 别名：
    Thrombospondin-type laminin G domain and EAR repeat-containing protein antibody; TSEAR_HUMAN antibody; TSP-EAR antibody; TSPEAR antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Thrombospondin-type laminin G domain and EAR repeat-containing protein (248-433AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TSPEAR Antibody (CSB-PA848817LA01HU)，的标记方式是Non-conjugated。对于TSPEAR Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA848817LB01HU TSPEAR Antibody, HRP conjugated ELISA
    FITC CSB-PA848817LC01HU TSPEAR Antibody, FITC conjugated
    Biotin CSB-PA848817LD01HU TSPEAR Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.
  • 基因功能参考文献：
    1. TSPEAR mutation is associated with tooth agenesis. PMID: 30046887
    2. using a luciferase-based reporter assay, we showed that TSPEAR knock-down is associated with decreased Notch signaling. In addition, NOTCH1 protein expression was reduced in patient scalp skin. Moreover, TSPEAR silencing in mouse hair follicle organ cultures was found to induce apoptosis in follicular epithelial cells, resulting in decreased hair bulb diameter PMID: 27736875
    3. TSPEAR expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    4. TSPEAR, cause disorders with auditory features: epilepsy, which can include auditory features in humans; audiogenic seizures in animals; and/or hearing impairments in humans and mice. PMID: 22678063
    5. The TSPEAR/C21orf29 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980

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  • 相关疾病：
    Deafness, autosomal recessive, 98 (DFNB98)
  • 亚细胞定位：
    Secreted. Cell surface. Cell projection, stereocilium.
  • 数据库链接：

    HGNC: 1268

    OMIM: 612920

    KEGG: hsa:54084

    STRING: 9606.ENSP00000321987

    UniGene: Hs.660703