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TRPM3 Antibody

  • 货号：
    CSB-PA884520LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA884520LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRPM3 Polyclonal antibody
  • Uniprot No.：
    Q9HCF6
  • 基因名：
    TRPM3
  • 别名：
    TRPM3 antibody; KIAA1616 antibody; LTRPC3 antibody; Transient receptor potential cation channel subfamily M member 3 antibody; Long transient receptor potential channel 3 antibody; LTrpC-3 antibody; LTrpC3 antibody; Melastatin-2 antibody; MLSN2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transient receptor potential cation channel subfamily M member 3 protein (1606-1713AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TRPM3 Antibody (CSB-PA884520LA01HU)，的标记方式是Non-conjugated。对于TRPM3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA884520LB01HU TRPM3 Antibody, HRP conjugated ELISA
    FITC CSB-PA884520LC01HU TRPM3 Antibody, FITC conjugated
    Biotin CSB-PA884520LD01HU TRPM3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. In addition, forms heteromultimeric ion channels with TRPM1 which are permeable for calcium and zinc ions.
  • 基因功能参考文献：
    1. this study shows that differential expression of TRPM3 and Ca2+ flux between NK cell subtypes may provide evidence for their role in the pathomechanism involving NK cell cytotoxicity activity in chronic fatigue syndrome/myalgic encephalomyelitis PMID: 27727448
    2. rs10780946 TRPM3 polymorphism is associated with asthma-exacerbated respiratory disease susceptibility. PMID: 26891941
    3. Phosphoinositols regulate TRPM3. PMID: 26517445
    4. Activation of TRPM3 channels increases the transcriptional activation potential of c-Fos in HEK293 cells. PMID: 26493679
    5. This is the first study to examine the involvement of TRPM channel gene variations on the risk of SSc incidence. Our results suggest roles of TRPM3 and TRPM5 gene variants in the susceptibility to or clinical expression of Systemic sclerosis PMID: 26546534
    6. The TRPM3 activity is rapidly and reversibly inhibited by activation of phosphatases. PMID: 26123194
    7. TRPM3 is a phosphoinositide-dependent ion channel. PMID: 26123195
    8. Missense mutation in the cation channel, TRPM3, underlies inherited cataract and glaucoma. PMID: 25090642
    9. TRPM3 channel activation changes the gene expression pattern of the cells by activating transcription of c-Jun-, ATF2-, and TCF-controlled genes. PMID: 25576487
    10. The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1. PMID: 25517751
    11. Pregnenolone sulfate is a powerful activator of TRPM3-mediated gene transcription, while transcription is completely inhibited by mefenamic acid in cells expressing activated TRPM3 channels. PMID: 24895737
    12. Data using recombinant proteins expressed in vascular endothelial cells suggest that SigmaR1 (sigma 1-type opioid receptor) is not involved in regulation of calcium signaling via TRPC5/TRPM3 (transient receptor potential cation channels C5/M3). PMID: 23121507
    13. TRPM3-ICF deletion mutation variants are regulatory channel subunits fine-tuning TRPM3 channel activity. PMID: 22961981
    14. Progesterone (0.01-10muM) suppressed TRPM3 activity evoked by pregnenolone sulphate. PMID: 22000496
    15. Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel. PMID: 22451665
    16. The inhibition of TRPM1 by zinc ions is primarily due to a short stretch of seven amino acids present only in the pore region of TRPM1 but not of TRPM3. PMID: 21278253
    17. Our data establish that TRPM3 channels constitute a regulated entry pathway for zinc ions in pancreatic beta-cells PMID: 20401728
    18. data suggest functional relevance of TRPM3 in contractile and proliferating phenotypes of vascular smooth muscle cells PMID: 20360246
    19. The hTRPM3 gene is comprised of 24 exons and maps to chromosome 9q-21.12 and is composed of 1555 amino acids with the characteristic six-transmembrane domain of TRPs and is expressed in kidney and, at lesser levels, in brain, testis, and spinal cord PMID: 12672827
    20. TRPM3 is the first ion channel activated by sphingolipids. PMID: 15550678
    21. the divalent cation selectivity of TRPM3 channels is regulated by altenrative splicing PMID: 15824111
    22. we give an overview of the identified TRPM3 variants and compare their functional properties--{REVIEW} PMID: 17217062
    23. TRPM3 did not reveal a otosclerosis-causing mutation PMID: 18224337

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM3 sub-subfamily
  • 组织特异性：
    Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in t
  • 数据库链接：

    HGNC: 17992

    OMIM: 608961

    KEGG: hsa:80036

    STRING: 9606.ENSP00000366314

    UniGene: Hs.47288