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  4. TRPC4 Antibody

TRPC4 Antibody

  • 中文名称：
    TRPC4兔多克隆抗体
  • 货号：
    CSB-PA025078GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBN4
  • 基因名：
    TRPC4
  • 别名：
    CCE1 antibody; HTRP 4 antibody; hTrp-4 antibody; hTrp4 antibody; MGC119570 antibody; MGC119571 antibody; MGC119572 antibody; MGC119573 antibody; RP11-10M8.1 antibody; Short transient receptor potential channel 4 antibody; STRPC4 antibody; Transient receptor potential 4 antibody; transient receptor potential cation channel subfamily C antibody; Transient receptor potential cation channel subfamily C member 4 antibody; transient receptor potential channel 4 antibody; TRP 4 antibody; trp related protein 4 antibody; Trp-related protein 4 antibody; TRP4 antibody; TRPC 4 antibody; TrpC4 antibody; TRPC4 protein antibody; TRPC4_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TRPC4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
  • 基因功能参考文献：
    1. Our results suggest that OGR1-dependent increases in TRPC4 expression may favor formation of highly Ca(2+) -permeable TRPC4-containing channels that promote transformed granule cell migration. Increased motility of cancer cells is a prerequisite for cancer invasion and metastasis, and our findings may point towards a key role for TRPC4 in progression of certain types of medullablastoma. PMID: 28627017
    2. Protein levels of TRPC4 were elevated in FCD II and tuberous sclerosis complex cortical samples compared to those of control samples. PMID: 28455787
    3. silencing of TRPC4 alleviates angiogenesis induced by oxidized low-density lipoprotein in human coronary artery endothelial cells through inactivation of VEGF and NF-kappaB. PMID: 26999308
    4. slow phase of Gi/o-mediated TRPC4 activation was diminished by inhibiting RhoA or enhancing PLCdelta function PMID: 26755577
    5. Studies indicate potential roles for Rasd1 small G protein and leptin in TRPC4 cation channel activation. PMID: 26083271
    6. Galpha(i2) activates the TRPC4 channel by direct binding. PMID: 25788576
    7. This study identifies a novel role for TRPC4 in the regulation of autophagy in vascular endothelial cells. PMID: 25476892
    8. a membrane-targeting domain of the transient receptor potential canonical (TRPC)4 channel unrelated to its formation of a tetrameric structure PMID: 25349210
    9. the S4-S5 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain. PMID: 23677990
    10. an essential role of Galpha(i) proteins as novel activators for TRPC4/5 and reveal the molecular mechanism by which G-proteins activate the channels. PMID: 22457348
    11. Report association of a TRPC4 SNP with myocardial infarction in population-based genetic studies. Higher Ca(2+) signals generated by TRPC4-I957V may facilitate generation of endothelium/nitric oxide-dependent vasorelaxation. PMID: 21427121
    12. Results showed a trend toward association of TRPC4 variants and photoparoxysmal response/idiopathic generalized epilepsies. PMID: 20574736
    13. SESTD1 was found to associate with TRPC4 and TRPC5 via the channel's calmodulin- and inositol 1,4,5-trisphosphate receptor-binding domain. PMID: 20164195
    14. Data show that TRPC4 co-precipitated with the junctional proteins beta-catenin and VE-cadherin. PMID: 19996314
    15. The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells PMID: 11830588
    16. Data demonstrate that the PDZ-interacting domain of TRPC4 controls its localization and surface expression in transfected HEK293 cells. PMID: 12154080
    17. TRPC4 is implicated in the regulation of calcium homeostasis in astrocytes, particularly as part of a signaling complex that forms at junctional sites between astrocytes. PMID: 15540229
    18. TRPC4 is a component of storeoperated channel in human corneal epithelial cells whose activation by EGF is requisite for an optimum mitogenic response to this growth factor PMID: 16033767
    19. Two tyrosine residues in the C terminus of human TRPC4 phosphorylated following epidermal growth factor (EGF) receptor stimulation of COS-7 cells. PMID: 16144838
    20. interaction of protein 4.1 with TRPC4 is required for activation of the endothelial ISOC channel. PMID: 16254212
    21. TRPC4 is an important component of the I(CRAC)-like channel in human gingival keratinocytes PMID: 17031666
    22. platelet capacitative Ca2+ entry channel complexes contain TRPC4 as a molecular component that determines sensitivity of capacitative Ca2+ entry to intracellular alkalosis. PMID: 17074721
    23. studies suggest an important role for TRPC4 in supporting Ca2+ entry--{REVIEW} PMID: 17217052
    24. TRPC4 channel expression was important for keratinocyte differentiation, as knocking out the channels (by siRNA strategy) prevented the induction of Ca(2+)-induced differentiation. PMID: 17920677
    25. results demonstrate that a direct interaction between hTRPC4 and the spectrin cytoskeleton is involved in the regulation of hTRPC4 surface expression and activation PMID: 18048348

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC4 sub-subfamily
  • 组织特异性：
    Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
  • 数据库链接：

    HGNC: 12336

    OMIM: 603651

    KEGG: hsa:7223

    STRING: 9606.ENSP00000369003

    UniGene: Hs.262960