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TROVE2 Antibody

  • 货号：
    CSB-PA13749A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TROVE2 antibody at 2µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 61, 24, 59, 60 kDa
      Observed band size: 61 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA13749A0Rb at dilution of 1:20
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA13749A0Rb at dilution of 1:20
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, Hela whole cell lysate, PC-3 whole cell lysate, Mouse heart tissue, Mouse spleen tissue, Mouse lung tissue
      All lanes: TROVE2 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 61, 24, 59, 60 kDa
      Observed band size: 61 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA13749A0Rb at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA13749A0Rb at dilution of 1:100
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Rat kidney tissue
      All lanes: TROVE2 antibody at 3.4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 61, 24, 59, 60 kDa
      Observed band size: 61 kDa
    • Immunofluorescent analysis of PC-3 cells using CSB-PA13749A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA13749A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The TROVE2 antibody is generated from rabbits immunized with a synthetic peptide between 3-535 amino acids from recombinant human TROVE2. Its purity is greater than 95% using protein G affinity chromatography purified. It exists as the unconjugated IgG isoform.

    This TROVE2 polyclonal antibody is reactive to human, mouse, and rat samples. It is suitable for the analysis of TROVE2 in ELISA, WB, IHC, and IF applications. This antibody can be used for the detection and localize the TROVE2 protein, aiding in TROVE2-related research.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TROVE2 Polyclonal antibody
  • Uniprot No.：
    P10155
  • 基因名：
    TROVE2
  • 别名：
    60 kDa ribonucleoprotein Ro antibody; 60 kDa Ro protein antibody; 60 kDa SS A/Ro ribonucleoprotein antibody; 60 kDa SS-A/Ro ribonucleoprotein antibody; Autoantigen Ro/SSA, 60-KD antibody; bA101E13.2 antibody; Gastric cancer multi drug resistance protein antibody; Ribonucleoprotein autoantigen SS A/Ro antibody; RO 60 antibody; Ro 60 kDa autoantigen antibody; RO60 antibody; RO60_HUMAN antibody; RoRNP antibody; Sjoegren syndrome antigen A2 antibody; Sjoegren syndrome type A antigen antibody; Sjogren syndrome antigen A2 (60kD ribonucleoprotein autoantigen SS A/Ro) antibody; Sjogren syndrome antigen A2 (60kDa ribonucleoprotein autoantigen SS A/Ro) antibody; Sjogren syndrome antigen A2 antibody; SS A antibody; SS-A antibody; SS-A/Ro antibody; SSA 2 antibody; SSA antibody; SSA2 antibody; TROVE 2 antibody; TROVE domain family member 2 antibody; TROVE2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human 60 kDa SS-A/Ro ribonucleoprotein protein (3-535AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TROVE2 Antibody (CSB-PA13749A0Rb)，的标记方式是Non-conjugated。对于TROVE2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA13749B0Rb TROVE2 Antibody, HRP conjugated ELISA
    FITC CSB-PA13749C0Rb TROVE2 Antibody, FITC conjugated
    Biotin CSB-PA13749D0Rb TROVE2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes.; May play roles in cilia formation and/or maintenance.
  • 基因功能参考文献：
    1. TROVE2 is a novel target of miR-128 in astrocytoma tissues and the expression of TROVE2 is increased with the pathological stages increasing. PMID: 26307612
    2. Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 and anti-La. PMID: 26725021
    3. These findings establish a link among the lupus autoantigen Ro60, Alu retroelements, and type I interferon. PMID: 26382853
    4. Findings indicate a relentless turnover of short-lived clonotypic variants, masquerading as long-lived Ro60 humoral autoimmunity. PMID: 23644453
    5. The Y3 RNA moiety of the Ro60 ribonucleoprotein plays a critical role in the pathogenesis of fetal cardiac injury by altering the subcellular location of Ro60 autoantibodies. PMID: 23698747
    6. these data indicate that ZBP1 may function as an adapter to export the Ro/Y3 RNA complex from nuclei. PMID: 22114317
    7. conclude that RNPs containing hY RNAs and Ro60, La or nucleolin are not required for the function of hY RNAs in chromosomal DNA replication in a human cell-free system, which can be mediated by Y RNAs outside of these RNPs PMID: 21060685
    8. dichotomy of human autoantibody responses against mutually exclusive determinants linked to a single domain of a systemic autoantigen and supports a model in which tolerance is broken by different immunogenic forms of Ro 60 PMID: 20131295
    9. Activation of Toll-like receptors by fetal factor Ro60-associated single-stranded RNA particles is relevant in autoimmune-associated congenital heart block, where the obligate maternal factor is an anti-SSA/Ro autoantibody. PMID: 20089705
    10. In viitro RNA chaperone activity of SSA2 was studied. PMID: 15928345
    11. The structural organization and Zn2+-dependent subdomain interactions involving autoiantigenic epitopes in the RBBC region of SS-A were studied. PMID: 15964842
    12. interactions between Ro-Y5 and L5-5S RNPs establish 5S RNA as a target of quality control PMID: 18056422
    13. results demonstrate that Ro 60 functions as a novel receptor for beta(2)GPI on the surface of apoptotic cells. The formation of Ro 60-beta(2)GPI complexes may protect against anti-Ro 60 autoantibody-mediated tissue injury. PMID: 19248095

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  • 亚细胞定位：
    Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  • 蛋白家族：
    Ro 60 kDa family
  • 数据库链接：

    HGNC: 11313

    OMIM: 600063

    KEGG: hsa:6738

    STRING: 9606.ENSP00000356411

    UniGene: Hs.288178