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TMPRSS11E Antibody

  • 货号：
    CSB-PA179468
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA179468(TMPRSS11E Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA179468(TMPRSS11E Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9UL52
  • 基因名：
    TMPRSS11E
  • 别名：
    TMPRSS11E antibody; DESC1 antibody; TMPRSS11E2 antibody; UNQ742/PRO1461 antibody; Transmembrane protease serine 11E antibody; EC 3.4.21.- antibody; Serine protease DESC1 antibody; Transmembrane protease serine 11E2) [Cleaved into: Transmembrane protease serine 11E non-catalytic chain; Transmembrane protease serine 11E catalytic chain] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human TMPRSS11E
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.
  • 基因功能参考文献：
    1. DESC1 may suppress esophageal squamous cell carcinoma development by sensitizing cells to apoptosis under an apoptotic stimulus through downregulating the EGFR/AKT signaling pathway. PMID: 26856390
    2. study demonstrates that two cellular serine proteases, DESC1 and MSPL, activate influenza viruses and emerging coronaviruses in cell culture and, because of their expression in human lung tissue, might promote viral spread in the infected host PMID: 25122802
    3. The domain of DESC1 exhibits a trypsin-like serine proteinase fold with a thrombin-like S1 pocket, a urokinase-type plasminogen activator-type S2 pocket, to accept small residues, and an open hydrophobic S3/S4 cavity to accept large hydrophobic residues. PMID: 17388811
  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.; [Transmembrane protease serine 11E catalytic chain]: Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 组织特异性：
    Expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testis.
  • 数据库链接：

    HGNC: 24465

    OMIM: 610399

    KEGG: hsa:28983

    STRING: 9606.ENSP00000307519

    UniGene: Hs.201877