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THOP1 Antibody

  • 货号：
    CSB-PA023508GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P52888
  • 基因名：
  • 别名：
    EC 3.4.24.15 antibody; Endopeptidase 24.15 antibody; EP24.15 antibody; MEPD_HUMAN antibody; MP78 antibody; Thimet oligopeptidase 1 antibody; Thimet oligopeptidase antibody; Thop1 antibody; THOP1_HUMAN antibody; TOP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human THOP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.
  • 基因功能参考文献：
    1. Data suggest that three new candidate genes involved in the development of rheumatoid arthritis (RA): ERBB2, TP53 and THOP1. PMID: 28148290
    2. THOP1 may have clinical potentials to be employed as a promising biomarker to identify individuals with better prognosis and a novel antitumor agent for therapy of patients with NSCLC PMID: 25180910
    3. Low THOP1 expression levels are associated with recurrence of hepatocellular carcinoma. PMID: 24604581
    4. TCEP. Data indicate that THIMET-oligopeptidase (TOP) oxidation by H2O2 and high valence states of hemeproteins does not lead to enzyme oligomerization. PMID: 24223886
    5. shear-dependent TOP induction down-regulates MHC1 levels, pointing to a role for TOP in the flow-mediated regulation of endothelial immunogenicity PMID: 23708739
    6. The semi-quantitative intracellular peptidome analyses of siRNA-transfected HEK293 cells shows that the levels of specific intracellular peptides are either increased or decreased upon EP24.15 inhibition. PMID: 22796113
    7. mediates antigen processing that generates cytotoxic T cell epitopes PMID: 21151101
    8. human thimet oligopeptidase crystal structure shows substrate recognition, regulation, and localization PMID: 14998993
    9. THIMET has a role in degradation of peptides generated by proteasomes PMID: 15328361
    10. EP24.15 associates with AT1 and B2 receptors both at the plasma membrane and after receptor internalization PMID: 15376229
    11. Mutations at only two residues (Glu-469 and Arg-498) are required to swap specificity with neurolysin, a result that is confirmed by testing the two-mutant constructs. PMID: 17251185
    12. increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load. PMID: 18571100
    13. Over 100 peptides were identified in human embryonic kidney 293 (HEK293) cells that are derived from intracellular proteins; many but not all of these peptides are substrates or products of EP24.15. PMID: 19282285
    14. interaction between EP24.15 and calmodulin is regulated within cells and is important for the stimulated secretion of EP24.15 from HEK293 cells. PMID: 19614740

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase M3 family
  • 数据库链接：

    HGNC: 11793

    OMIM: 601117

    KEGG: hsa:7064

    STRING: 9606.ENSP00000304467

    UniGene: Hs.78769