Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. TGFBRAP1 Antibody

TGFBRAP1 Antibody

  • 货号：
    CSB-PA819888LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA819888LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TGFBRAP1 Polyclonal antibody
  • Uniprot No.：
    Q8WUH2
  • 基因名：
    TGFBRAP1
  • 别名：
    TGFBRAP1 antibody; Transforming growth factor-beta receptor-associated protein 1 antibody; TGF-beta receptor-associated protein 1 antibody; TRAP-1 antibody; TRAP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transforming growth factor-beta receptor-associated protein 1 protein (401-600AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TGFBRAP1 Antibody (CSB-PA819888LA01HU)，的标记方式是Non-conjugated。对于TGFBRAP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA819888LB01HU TGFBRAP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA819888LC01HU TGFBRAP1 Antibody, FITC conjugated
    Biotin CSB-PA819888LD01HU TGFBRAP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo.
  • 基因功能参考文献：
    1. Vps3 and Vps8 are required for recycling of beta1 integrins. PMID: 29476049
    2. MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be risk or protect factors in prognosis of ADC; HTR2B, DPP4, and TGFBRAP1 genes may be risk factors in prognosis of SQC. PMID: 27301951
    3. the association of rs2679860 polymorphisms of TGFBRAP1 and DBP variation as well as plasma levels of TGF-beta1 PMID: 25856002
    4. In the absence of Langerhans cells (LC), contact hypersensitivity (CHS) reactions in langerin-positive dendritic cell-specific TGF-betaR1-deficient mice are diminished, providing further evidence against a regulatory role for LC in CHS. PMID: 21998450
  • 亚细胞定位：
    Cytoplasm. Early endosome. Note=Colocalizes with TGF-beta receptors in the absence of signaling.
  • 蛋白家族：
    TRAP1 family
  • 数据库链接：

    HGNC: 16836

    OMIM: 606237

    KEGG: hsa:9392

    STRING: 9606.ENSP00000258449

    UniGene: Hs.446350