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TEAD3 Antibody

  • 货号：
    CSB-PA050233
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q99594
  • 基因名：
  • 别名：
    DTEF 1 antibody; DTEF-1 antibody; DTEF1 antibody; ETFR 1 antibody; ETFR1 antibody; TEA domain family member 3 antibody; TEA domain family member 5 antibody; TEAD 3 antibody; TEAD-3 antibody; Tead3 antibody; TEAD3_HUMAN antibody; TEAD5 antibody; TEF 5 antibody; TEF5 antibody; Transcriptional enhancer factor 5 antibody; Transcriptional enhancer factor TEF 5 (DTEF 1) antibody; Transcriptional enhancer factor TEF 5 antibody; Transcriptional enhancer factor TEF-5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TEF-5.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
  • 基因功能参考文献：
    1. Sequences at the 9p21.3 risk locus disrupt TEAD factor binding and TEAD3-dependent TGF-beta induction of p16 in HAoSMCs. TEAD3 overexpression induced p16 in HAoSMCs homozygous for the nonrisk coronary disease allele, but not for the risk allele. PMID: 26487755
    2. Transcription enhancer factor-5 and the GATA-like protein act in a coordinate manner to determine the placental-specific expression of the human 3beta-hydroxysteroid dehydrogenase/isomerase I enzyme PMID: 15131259
    3. The paper described that the translation initiation codon for the TEF-5 protein was a non-AUG (AUA) codon. PMID: 10379887
    4. The paper described that the translation initiation codon for the TEF-5 protein was a non-AUG (ATA) codon. PMID: 9148898
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Preferentially expressed in the placenta.
  • 数据库链接：

    HGNC: 11716

    OMIM: 603170

    KEGG: hsa:7005

    STRING: 9606.ENSP00000345772

    UniGene: Hs.485205