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STXBP4 Antibody

  • 货号：
    CSB-PA285123
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA285123(STXBP4 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q6ZWJ1
  • 基因名：
    STXBP4
  • 别名：
    FLJ16496 antibody; MGC149829 antibody; MGC50337 antibody; OTTHUMP00000082667 antibody; OTTHUMP00000227400 antibody; STX4-interacting protein antibody; STXB4_HUMAN antibody; Stxbp4 antibody; Synip antibody; Syntaxin 4 interacting protein antibody; Syntaxin 4-interacting protein antibody; Syntaxin binding protein 4 antibody; Syntaxin-binding protein 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human STXBP4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.
  • 基因功能参考文献：
    1. High STXBP4 expression is associated with squamous cell carcinogenesis. PMID: 29735662
    2. The deleterious SNPs localized in STXBP4 and ZNF404 genes were identified which might play a role in breast cancer development by dysregulating its gene expression. PMID: 28422318
    3. Expression studies in breast tumor tissues found SNP rs2787486 to be associated with increased STXBP4 expression, suggesting this may be a target gene of this locus. PMID: 27600471
    4. Whole transcriptome sequencing followed by pathway analysis indicated that STXBP4 is involved in functional gene networks that regulate cell growth, proliferation, cell death, and survival in cancer. Platelet-derived growth factor receptor alpha (PDGFRalpha) was a key downstream mediator of STXBP4 function. In line with this, shRNA mediated STXBP4 and PDGFRA knockdown suppressed tumor growth in soft-agar and xenograft ... PMID: 28087642
    5. meta-analysis suggested that polymorphism STXBP4/COX11 rs6504950 variant was significantly associated with breast cancer risk; the A allele of rs6504950 decreased the risk of breast cancer PMID: 22863968
    6. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20416077
    7. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20095854
    8. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20145138
    9. Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cells PMID: 12855681
    10. Stxbp4 and RACK1, two scaffold proteins, play central roles in balancing DeltaNp63 protein levels. While Stxbp4 functions to stabilize DeltaNp63 proteins, RACK1 targets DeltaNp63 for degradation. PMID: 19451233

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  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    HGNC: 19694

    OMIM: 610415

    KEGG: hsa:252983

    STRING: 9606.ENSP00000365530

    UniGene: Hs.35199