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STRN Antibody

  • 货号：
    CSB-PA022880DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA022880DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STRN Polyclonal antibody
  • Uniprot No.：
    O43815
  • 基因名：
    STRN
  • 别名：
    MGC125642 antibody; SG2NA antibody; Striatin antibody; Striatin Calmodulin binding protein antibody; STRN antibody; STRN_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Striatin protein (581-780AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.
  • 基因功能参考文献：
    1. striatin-associated Salt Sensitive Blood Pressure is associated with normal plasma renin activity and reduced epinephrine levels PMID: 28985281
    2. The prevalence of STRN-ALK kinase fusions were determined in papillary thyroid cancer of an adult population PMID: 29046324
    3. In this review, we summarize the current understanding of the assembly and functions of STRIPAK complexes( striatin-centered multicomponent supramolecular structures containing both kinases and phosphatases), with a special focus on cell signaling and cancer PMID: 26876214
    4. we report 2 cases of renal cell carcinomas harboring a novel STRN-ALK fusion PMID: 26848800
    5. the "multimodulator" scaffold roles of striatins in the initiation and regulation of the formation of various complex particles and structures, are discussed. PMID: 25501894
    6. PP2A/striatin complex modulates microtubule dynamics by regulating MAP2 phosphorylation PMID: 25497017
    7. the rapid, nongenomic mineralocorticoid receptor pathway (mediated via striatin) has a role in modulating the interaction between salt intake and blood pressure. PMID: 25368024
    8. A recurrent STRN/ALK fusion found in thyroid carcinomas. PMID: 24475247
    9. Our data demonstrate that STRN-ALK fusion occurs in a subset of patients with highly aggressive types of thyroid cancer and provide initial evidence suggesting that it may represent a therapeutic target for these patients. PMID: 24613930
    10. Striatin orchestrates the regulation of Mst3 by PP2A. PMID: 21985334
    11. identify striatin as a molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways PMID: 15569929
    12. Taken together, splicing variation of SG2NA might have some critical roles in differentiation and maturation in metazoan cells. PMID: 18571342
    13. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, dendritic spine.
  • 蛋白家族：
    WD repeat striatin family
  • 组织特异性：
    Preferentially expressed in brain.
  • 数据库链接：

    HGNC: 11424

    OMIM: 614765

    KEGG: hsa:6801

    STRING: 9606.ENSP00000263918

    UniGene: Hs.127486