Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. SSX1 Antibody

SSX1 Antibody

  • 货号：
    CSB-PA005093
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 22RV-1 SW480 cells using SSX Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q16384
  • 基因名：
    SSX1
  • 别名：
    Cancer/testis antigen 5.1 antibody; Cancer/testis antigen family 5 member 1 antibody; CT5.1 antibody; MGC150425 antibody; MGC5162 antibody; Protein SSX1 antibody; sarcoma; synovial; X chromosome related 1 antibody; SSRC antibody; SSX1 antibody; SSX1_HUMAN antibody; Synovial sarcoma antibody; Synovial sarcoma; X breakpoint 1 antibody; X breakpoint 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human SSX.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Could act as a modulator of transcription.
  • 基因功能参考文献：
    1. SS18-SSX1 deregulates developmental programs to drive transformation by hijacking a transcriptional repressive complex to aberrantly activate gene expression PMID: 29502955
    2. Synovial sarcoma (SS) is considered as high-grade tumors with a poor prognosis. Novel therapies targeted at fusion oncogene, SS18-SSX-derived peptide vaccine, epidermal growth factor receptor, and vascular endothelial growth factor are the future hope in SS. PMID: 29893303
    3. Data indicate that the oncogene SS18-SSX1 promotes tumorigenesis by increasing the expression of SHC SH2-domain binding protein 1 (SHCBP1), which normally acts as a tumor promoting factor. PMID: 27572315
    4. In patients with Colon cancer, the expression of SSX1 gene was associated with a poor prognosis. PMID: 28631709
    5. Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18-SSX2 tumors. Re-analysis of human SS18-SSX1 and SS18-SSX2 tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 expression in SS18-SSX1 tumors. PMID: 26947017
    6. Data show that SS18/SSX tightly regulates the elevated expression of the key Wnt target AXIN2 in primary synovial sarcoma. PMID: 26905812
    7. a rare variant of the SS18-SSX1 fusion transcript, which could not be identified by routine procedures for genetic diagnosis, was detected. In addition, 8 missense mutations of cancer-related genes were confirmed PMID: 25959879
    8. SS18-SSX-induced Wnt/beta-catenin signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression. PMID: 24166495
    9. The mRNA levels of SSX1 and SSX4 are associated with multiple myeloma clinical stage PMID: 24710929
    10. These results suggest that the characteristic speckle localization pattern of SS18-SSX is strongly involved in the tumorigenesis through the SSX moiety of the SS18-SSX fusion protein. PMID: 24130893
    11. Knockdown of SS18-SSX1 in synovial sarcoma inhibits viability and induces apoptosis. PMID: 23716114
    12. Study shows that the SS18-SSX1 oncogenic fusion usurps SWI/SNF-like BAF complexes, resulting in activation of Sox2, which drives proliferation. PMID: 23540691
    13. siRNA targeting of SS18-SSX1 has therapeutic potential for the treatment of synovial sarcoma. PMID: 20198325
    14. epigenetic features may define the cellular microenvironment in which SYT-SSX displays its functional effects PMID: 19936258
    15. existence of fusion with SYT in synovial sarcoma PMID: 12037676
    16. A synovial sarcoma of classic morphology contained a novel t(20;X) SS18L1(strong homology to SS18 on Ch20)/SSX1 fusion transcript in which nucleotide 1216 (exon 10) of SS18L1 was fused in-frame with nucleotide 422 (exon 6) of SSX1. PMID: 12696068
    17. RT-PCR detection of SSX1 in paraffin-embedded tissue allowed for molecular diagnosis of synovial sarcoma. PMID: 15735574
    18. demonstrate differentially expressed genes for the 2 major gene fusion variants in SS, chromosome 18 synovial sarcoma (SS18)/SSX1 and SS18/SSX2, and thereby suggest that these result in different downstream effects PMID: 16152617
    19. SYT-SSX1 induces insulin-like growth factor II expression in fibroblast cells. PMID: 16247461
    20. In conclusion, SS18-SSX and IGF-1R seem to play important but different roles in maintaining malignant growth of synovial sarcoma cells. PMID: 18267106
    21. siRNA targeting of SS18-SSX1 may have therapeutic potential in the treatment of synovial sarcomas. PMID: 18714179
    22. We evaluated the correlations among the expression levels of NY-ESO-1, LAGE-1 and SSX-1 and clinical parameters in hepatocellular carcinoma patients PMID: 19212631

    显示更多

    收起更多

  • 相关疾病：
    A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
  • 蛋白家族：
    SSX family
  • 组织特异性：
    Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and
  • 数据库链接：

    HGNC: 11335

    OMIM: 312820

    KEGG: hsa:6756

    STRING: 9606.ENSP00000366118

    UniGene: Hs.434142