SRGN Antibody

1. SRGN overexpression promoted colorectal cancer cell migration and invasion and SRGN was physically binding to a hypoxia response element in its promoter region. PMID: 30121667
2. SRGN secreted by tumor cells and stromal components in the TME promotes malignant phenotypes through interacting with tumor cell receptor CD44 PMID: 27819672
3. Extracellular spce serglycin upregulated CD44 receptor expression to maintain nasopharyngeal carcinoma stemness by interacting with CD44 and activating the MAPK/beta-catenin pathway. PMID: 27809309
4. SRGN expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
5. Patients with NPC with tumors showing strong tumor intensity and low infiltrated percentage of tumor-infiltrated lymphocytes with serglycin may be at high risk for distant metastases. PMID: 24995621
6. The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression PMID: 26581653
7. These results suggest functions for serglycin in endothelial cells trough interactions with partner molecules, in biological processes with relevance for diabetic complications, cardiovascular disease and cancer development. PMID: 26694746
8. These results suggest that different signaling pathways are involved in regulating secretion of serglycin and partner molecules in activated endothelial cells. PMID: 24513305
9. The reduced expression of SRGN was accompanied by elevated levels of E-cadherin. PMID: 23996242
10. These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM. PMID: 24403068
11. These results suggest that human epicardial adipose tissue (EAT) has strong inflammatory properties in patients with coronary artery disease and provide novel evidence that serglycin is an adipocytokine highly expressed in EAT. PMID: 23376071
12. Cell-surface SRGN promotes the adhesion of myeloma cells to collagen type I. PMID: 23387827
13. This review covers recent studies on the involvement of serglycin in various pathological conditions, as well as its roles in immunity, hemostasis, cell growth, apoptosis, and reproduction. PMID: 22807344
14. Human granulocyte precursors transfected with siRNA against serglycin displayed reduced capability to retain fully processed HNP-1. PMID: 21849484
15. Serglycin regulates NPC metastasis via autocrine and paracrine routes, and that it serves as an independent prognostic indicator of metastasis-free survival and disease-free survival in NPC patients. PMID: 21289131
16. Serglycin secreted by human multiple myeloma cell lines inhibits both the classical and lectin pathways of complement, without influencing alternative pathway activity. PMID: 21268013
17. Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. PMID: 21075844
18. proapoptotic granzyme is exocytosed predominantly as a macromolecular complex with serglycin PMID: 12388539
19. cell- and differentiation-specific alterations in chromatin structure may control serglycin gene expression PMID: 14506241
20. serglycin-bound granzyme B in high-molecular-weight degranulate material from cytotoxic T lymphocytes predominantly followed a dynamin-dependent pathway to kill target cells PMID: 14739229
21. mechanism of delivery is proposed entailing electrostatic transfer of granzyme B from serglycin to cell surface proteins PMID: 15788411
22. Serglycin release is a constitutive process, which may be of fundamental biological importance in the study of multiple myeloma. PMID: 16870619
23. Serglycin is of importance for secretory processes in human monocytes. PMID: 17909965
24. Mutations in SRGN is not associated with familial hemophagocytic lymphohistiocytosis PMID: 18000860

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HGNC: 9361

OMIM: 177040

KEGG: hsa:5552

STRING: 9606.ENSP00000242465

UniGene: Hs.1908