Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. SPC25 Antibody

SPC25 Antibody

  • 中文名称：
    SPC25兔多克隆抗体
  • 货号：
    CSB-PA881019LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA881019LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SPC25 Polyclonal antibody
  • Uniprot No.：
    Q9HBM1
  • 基因名：
    SPC25
  • 别名：
    AD024 antibody; hSpc25 antibody; Kinetochore protein Spc25 antibody; SPBC25 antibody; SPC25 antibody; SPC25_HUMAN antibody; spindle pole body component 25 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Kinetochore protein Spc25 protein (1-224AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SPC25 Antibody (CSB-PA881019LA01HU)，的标记方式是Non-conjugated。对于SPC25 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA881019LB01HU SPC25 Antibody, HRP conjugated ELISA
    FITC CSB-PA881019LC01HU SPC25 Antibody, FITC conjugated
    Biotin CSB-PA881019LD01HU SPC25 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
  • 基因功能参考文献：
    1. SPC25 overexpression significantly increased the cancer stem cell properties and invasion of A549 cells. PMID: 29432994
    2. SPC25 expressed by extracellular matrix stiffening is required for lung cancer cell proliferation. PMID: 29709477
    3. SPC25 overexpression is associated with Breast Cancer. PMID: 27197203
    4. hSPC25 is an essential kinetochore component that plays a significant role in proper execution of mitotic events PMID: 14699129
    5. the Spc24, Spc25, Nuf2, and Ndc80/Hec1 complex is a faithful copy of the endogenous Ndc80 complex PMID: 15961401

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    SPC25 family
  • 数据库链接：

    HGNC: 24031

    OMIM: 609395

    KEGG: hsa:57405

    STRING: 9606.ENSP00000282074

    UniGene: Hs.421956