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SOX6 Antibody

  • 货号：
    CSB-PA030202
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P35712
  • 基因名：
    SOX6
  • 别名：
    HSSOX 6 antibody; HSSOX6 antibody; SOX 6 antibody; sox6 antibody; SOX6_HUMAN antibody; SOXD antibody; SRY (sex determining region Y) box 6 antibody; SRY box 6 antibody; SRY box containing gene 6 antibody; Transcription factor SOX 6 antibody; Transcription factor Sox-6 antibody; Transcription factor SOX6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat,Monkey
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Sox-6.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor.
  • 基因功能参考文献：
    1. found no significant differences in the genetic distribution and allelic frequency of MYB and SOX-6 gene polymorphisms PMID: 30200835
    2. miR-96 could promote cell proliferation, migration, and invasion in HCC by targeting SOX6 PMID: 28892647
    3. Chromatin immunoprecipitation (ChIP), quantitative ChIP and dual luciferase activity assays were used to confirm the binding of SOX6 to the promoter region of TWIST1. PMID: 29512775
    4. miR-671 promotes prostate cancer cell proliferation by inhibiting SOX6 PMID: 29355560
    5. This is the first report on gamma-globin induction by downregulation of SOX6 in human erythroblasts derived from beta-thalassemia major. PMID: 29333458
    6. Low SOX6 expression is associated with Glioma. PMID: 28687615
    7. the SOX6 gene is potentially targeted by five MicroRNAs that are up-regulated only in Hereditary persistence of fetal hemoglobin deletion type-2, compared to Sicilian-deltabeta-thalassemia and controls. PMID: 27591578
    8. Our observations revealed that SOX6 is a tumor suppressor in ovarian cancer cells, and SOX6 exerts an inhibitory effect on the proliferation, invasion, and tumor cell-induced angiogenesis of ovarian cancer cells, whereas nerin-1 plays an opposite role and its expression is inversely correlated with SOX6. PMID: 28475012
    9. SOX6 rs16933090 affects coronary calcium score obtained at CT angiography, but plays minor role in the development of subclinical atherosclerosis in subjects with type 2 diabetes. PMID: 26868133
    10. The highly conserved high-mobility group (HMG) domain of SOX6 is required for SOX6-mediated p53 stabilization and tumor inhibitory activity. PMID: 26119940
    11. SOX6 is a novel regulator of adipogenesis synergizing with epigenetic mechanisms. PMID: 26893351
    12. results suggest that miR-208 represents a potential onco-miR and participates in ESCC carcinogenesis by suppressing SOX6 expression PMID: 25023649
    13. Findings provide evidence for the first time that SOX6 expression was decreased in hepatocellular carcinoma. PMID: 23731550
    14. L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity PMID: 22547066
    15. Genetic variants in the SOX6 gene are associated with bone mineral density in both Caucasian and Chinese populations PMID: 21625884
    16. SOX trio gene and protein decreased with advancement of osteoarthritis in human articular cartilage. PMID: 21728837
    17. The SOX6 is a novel tumor-suppressor gene in ESCC development and is a potential prognostic marker in esophageal squamous cell carcinoma. PMID: 21084391
    18. identified SOX5 and SOX6 as the first two SHOX-interacting proteins and have shown that this interaction regulates aggrecan expression, an essential factor in chondrogenesis and skeletal development. PMID: 21262861
    19. Sox6 enhances erythroid differentiation in human erythroid progenitors. PMID: 21263153
    20. Results support the SOX6 gene as an important gene for bone mineral density variation. PMID: 21104366
    21. SOX6 was previously found to be essential to both cartilage formation/chondrogenesis and obesity-related insulin resistance, suggesting the gene's dual role in both bone and fat PMID: 19714249
    22. SOX6 may be a potential diagnostic marker for gliomas. PMID: 15696967
    23. SOX6 may be a useful marker for the diagnosis of tumors arising from immature bipotential cells that may differentiate into neuronal and glial cells. PMID: 15696972
    24. co-expression of SOX6 with SUMO2 results in the appearance of SOX6 in a punctate nuclear pattern that colocalized with promyelocytic leukemia protein, which was partially abolished by mutations in SOX6 sumoylation sites PMID: 16442531
    25. Thus, we successfully identified the Sox6 promoter and its core enhancer and characterized the interactions with regulatory transcription factors. PMID: 17433257
    26. Results suggest that DAX-1 and SOX6 proteins interact, have overlapped expression in the testis, and act antagonistically during pre-mRNA splicing. PMID: 19384854
    27. Although Sox6 is not required for specification of medial ganglionic eminence (MGE)-derived cortical interneurons, Sox6 gene is necessary for the normal positioning and maturation of these cells. PMID: 19709629

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Expressed in a wide variety of tissues, most abundantly in skeletal musclen.
  • 数据库链接：

    HGNC: 16421

    OMIM: 607257

    KEGG: hsa:55553

    STRING: 9606.ENSP00000324948

    UniGene: Hs.368226