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SNRPD1 Antibody

  • 货号：
    CSB-PA022332LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA022332LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA022332LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate
      All lanes: SNRPD1 antibody at 2.4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 14 kDa
      Observed band size: 14 kDa
  • 其他：

产品详情

  • 产品描述：

    The CSB-PA022332LA01HU polyclonal antibody against SNRPD1 was generated in rabbits using recombinant human small nuclear ribonucleoprotein Sm D1 protein (1-119aa) as the immunogen. The resulting antibody was purified using protein G affinity chromatography and achieved a purity level of up to 95%.

    This SNRPD1 polyclonal antibody is specific to human SNRPD1 proteins and can be utilized to identify the endogenous levels of SNRPD1 protein. Quality testing has been conducted for ELISA, WB, IHC, and IF applications, allowing users to detect, identify, and trace the SNRPD1 protein with this antibody.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SNRPD1 Polyclonal antibody
  • Uniprot No.：
    P62314
  • 基因名：
    SNRPD1
  • 别名：
    AA407109 antibody; AL023031 antibody; HsT2456 antibody; Sm D1 antibody; Sm-D autoantigen antibody; Sm-D1 antibody; Small nuclear ribonucleoprotein D1 polypeptide antibody; Small nuclear ribonucleoprotein Sm D1 antibody; SmD autoantigen antibody; SMD1 antibody; SMD1_HUMAN antibody; snRNP core protein D1 antibody; SNRPD antibody; Snrpd1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Small nuclear ribonucleoprotein Sm D1 protein (1-119AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SNRPD1 Antibody (CSB-PA022332LA01HU)，的标记方式是Non-conjugated。对于SNRPD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022332LB01HU SNRPD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA022332LC01HU SNRPD1 Antibody, FITC conjugated
    Biotin CSB-PA022332LD01HU SNRPD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
  • 基因功能参考文献：
    1. Data show that the elevation of cerebrospinal fluid anti-Sm antibodies through transudation from systemic circulation due to damaged blood-brain barrier (BBB) plays a critical role in the pathogenesis of acute confusional state (ACS). PMID: 25273532
    2. The interaction of SMN with the spliceosomal SmD1 (also known as SNRPD1), severely decreases SMN-coilin interaction and prevents Cajal body assembly. PMID: 24413165
    3. Overexpression of SNRPD1 is associated with highly aggressive breast cancers. PMID: 23358685
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    SnRNP core protein family
  • 数据库链接：

    HGNC: 11158

    OMIM: 601063

    KEGG: hsa:6632

    STRING: 9606.ENSP00000300413

    UniGene: Hs.464734