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SMG6 Antibody

  • 货号：
    CSB-PA773032LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA773032LA01HU at dilution of 1:100
    • Immunohistochemistry analysis of human endometrial cancer using CSB-PA773032LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA773032LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SMG6 Polyclonal antibody
  • Uniprot No.：
    Q86US8
  • 基因名：
    SMG6
  • 别名：
    SMG6 antibody; C17orf31 antibody; EST1A antibody; KIAA0732Telomerase-binding protein EST1A antibody; EC 3.1.-.- antibody; EST1-like protein A antibody; Ever shorter telomeres 1A antibody; Smg-6 homolog antibody; Telomerase subunit EST1A antibody; hSmg5/7a antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Telomerase-binding protein EST1A protein (251-511AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SMG6 Antibody (CSB-PA773032LA01HU)，的标记方式是Non-conjugated。对于SMG6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA773032LB01HU SMG6 Antibody, HRP conjugated ELISA
    FITC CSB-PA773032LC01HU SMG6 Antibody, FITC conjugated
    Biotin CSB-PA773032LD01HU SMG6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).; Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA.
  • 基因功能参考文献：
    1. Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture. PMID: 28461625
    2. Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways. PMID: 27864472
    3. A preferred sequence motif spanning most SMG6 cleavage sites has been discovered by analysis of endogenous non-sense-mediated mRNA decay targets. PMID: 25429978
    4. SMG6 requires UPF1 and SMG1 for nonsense-mediated mRNA decay. PMID: 25053839
    5. The study demonstrates that SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network. PMID: 25013172
    6. Consistent with involvement of SMG6 in the decay process full-length nonsense-containing beta-globin mRNA was increased and the Delta169 decay intermediate was decreased in cells knocked down for SMG6. PMID: 24086375
    7. The tricotetrapeptide repeat-containing domain within Est1A was sufficient for interaction with hTERT. PMID: 22011238
    8. Data show that SMG6 interacts directly with the EJC via two conserved EJC-binding motifs (EBMs). PMID: 20930030
    9. associated with most or all active telomerase in HeLa cell extracts; overexpression of hEST1A induces anaphase bridges due to chromosome-end fusions, and telomeric DNA persists at the fusion points PMID: 12676087
    10. Human EST1A is associated with most or all active telomerase and is involved either directly or indirectly in telomere elongation and telomere capping. PMID: 16820686
    11. Structural properties of the PIN domain indicate its putative active center consisting of invariant acidic amino acid residues, which is similar to the active center of 5' nucleases. PMID: 17557331
    12. Report shows that hEST1A assembles specifically with telomerase in the context of the telomerase RNA (hTR)-hTERT ribonucleoprotein, through the high affinity of hEST1A for hTR and specific protein-protein contacts with hTERT. PMID: 17940095

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  • 亚细胞定位：
    Nucleus, nucleolus. Chromosome, telomere. Cytoplasm, cytosol. Note=Particularly enriched in the nucleolus.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 17809

    OMIM: 610963

    KEGG: hsa:23293

    STRING: 9606.ENSP00000263073

    UniGene: Hs.448342