SLC6A12 Antibody
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货号:CSB-PA021690ESR2HU
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规格:¥440
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促销:
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图片:
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其他:
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) SLC6A12 Polyclonal antibody
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Uniprot No.:P48065
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基因名:SLC6A12
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别名:Betaine/GABA transporter 1 antibody; BGT-1 antibody; BGT1 antibody; Gamma aminobutyric acid transporter antibody; GAT2 antibody; Na(+)/Cl(-) betaine/GABA transporter antibody; S6A12_HUMAN antibody; Slc6a12 antibody; Sodium- and chloride-dependent betaine transporter antibody; Solute carrier family 6 (neurotransmitter transporter), member 12 antibody; Solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 antibody; Solute carrier family 6 member 12 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Sodium- and chloride-dependent betaine transporter protein (515-614AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:Antigen Affinity Purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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产品提供形式:Liquid
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应用范围:ELISA, IHC
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推荐稀释比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
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基因功能参考文献:
- The SLC6A12 expression levels in peripheral blood mononuclear cells were significantly higher in TLE patients. PMID: 26690518
- T40 may be important for the trafficking and insertion of BGT1 in the plasma membrane PMID: 24829506
- JAK2 is a novel regulator of the GABA transporter BGT1. PMID: 22405821
- This study found that rs216250 of SLC6A12 was correlated with the Scale for the Assessment of Negative Symptoms (SANS) scores. PMID: 21367462
- Results showed that two polymorphisms and a haplotype in SLC6A12, were significantly associated with AIA after multiple testing corrections. PMID: 20597903
- The primary structure of BGT-1 predicts two putative phosphorylation sites for the Ca2+/diacylglycerol-dependent protein kinase (PKC), which regulates BGT-1 function by phosphorylation events in a transport system expressed in cultured astrocytoma cells. PMID: 12111824
- BGT-1 is expressed from mRNA and transports GABA in platelets. PMID: 16198020
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亚细胞定位:Membrane; Multi-pass membrane protein.
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蛋白家族:Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A12 subfamily
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组织特异性:Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.
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数据库链接:
HGNC: 11045
OMIM: 603080
KEGG: hsa:6539
STRING: 9606.ENSP00000352702
UniGene: Hs.437174
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