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SLC30A7 Antibody

  • 货号：
    CSB-PA021572GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8NEW0
  • 基因名：
  • 别名：
    SLC30A7; ZNT7; ZNTL2; Zinc transporter 7; ZnT-7; Solute carrier family 30 member 7; Znt-like transporter 2
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SLC30A7
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP.
  • 基因功能参考文献：
    1. We observed Bonferroni-corrected statistically significant interactions between albuminuria, urine cadmium levels and polymorphisms in gene SLC30A7 and RAC1. PMID: 28558300
    2. Overexpression of ZnT7 is accompanied by activation of PI3K/Akt pathway and inhibiting HG-induced apoptosis. PMID: 23275032
    3. Intracellular transporters such as ZnT7, influence the transcellular movement of zinc across the enterocyte PMID: 21462106
    4. hZnT-7 is up-regulated in response to cellular zinc depletion in Raji & THP-1 cells. PMID: 17971500
    5. Data show that ZNT7 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. PMID: 18639746

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  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
  • 数据库链接：

    HGNC: 19306

    OMIM: 611149

    KEGG: hsa:148867

    STRING: 9606.ENSP00000350278

    UniGene: Hs.533903