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SHANK1 Antibody

  • 货号：
    CSB-PA100838
  • 规格：
    ￥1100
  • 图片：
    • Gel: 6%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA100838(SHANK1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y566
  • 基因名：
  • 别名：
    GKAP/SAPAP interacting protein antibody; OTTHUMP00000174437 antibody; SH3 and multiple ankyrin repeat domains 1 antibody; SH3 and multiple ankyrin repeat domains protein 1 antibody; SH3/ankyrin domain gene 1 antibody; SHAN1_HUMAN antibody; SHANK 1 antibody; Shank1 antibody; Shank1a antibody; Somatostatin receptor interacting protein antibody; Somatostatin receptor-interacting protein antibody; SPANK 1 antibody; SPANK1 antibody; SSTR interacting protein antibody; SSTR-interacting protein antibody; SSTRIP antibody; Synamon antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human SHANK1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
  • 基因功能参考文献：
    1. s summarize and discuss behavioral and neuronal findings obtained in the Shank1 knockout mouse model for Autism spectrum disorder (ASD); identify open research questions by comparing such findings with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions; conclude by discussing the implications of the behavioral and neuronal phenotypes displayed by the Shank1 knockout mouse model. PMID: 28963042
    2. SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane. PMID: 28263956
    3. Data show that the Shank1 protein mRNA 3' UTR adopts two very stable intramolecular G-quadruplexes which are bound specifically and with high affinity by X mental retardation protein (FMRP). PMID: 25692235
    4. a non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA PMID: 24533096
    5. The results of this study suggested a role of SHANK1 in working memory deficits in schizophrenia. PMID: 21901269
    6. A hemizygous SHANK1 deletion segregates in a four-generation family in which male carriers--but not female carriers--have autism spectrum disorder with higher functioning. PMID: 22503632
    7. Results show that dendritic targeting of shank1 mRNA granules involves KIF5C and the KIF5-associated RNA-binding protein staufen1. PMID: 19416473

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  • 亚细胞定位：
    Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
  • 蛋白家族：
    SHANK family
  • 组织特异性：
    Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
  • 数据库链接：

    HGNC: 15474

    OMIM: 604999

    KEGG: hsa:50944

    STRING: 9606.ENSP00000293441

    UniGene: Hs.274255