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SCN7A Antibody

  • 货号：
    CSB-PA2108ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA2108ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SCN7A Polyclonal antibody
  • Uniprot No.：
    Q01118
  • 基因名：
    SCN7A
  • 别名：
    SCN7A antibody; SCN6A antibody; Sodium channel protein type 7 subunit alpha antibody; Putative voltage-gated sodium channel subunit alpha Nax antibody; Sodium channel protein cardiac and skeletal muscle subunit alpha antibody; Sodium channel protein type VII subunit alpha antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sodium channel protein type 7 subunit alpha protein (265-368AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
  • 基因功能参考文献：
    1. The s demonstrated that the sodium channel Nax functions as a sodium sensor. With increased extracellular sodium, Nax up-regulates prostasin, which results in activation of the sodium channel ENaC. PMID: 26537257
    2. SNP rs7565062 of SCN7A was significantly associated with essential hypertension in a Northern Han Chinese population PMID: 25393565
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium channel (TC 1.A.1.10) family, SCN7A subfamily
  • 组织特异性：
    Heart and uterus.
  • 数据库链接：

    HGNC: 10594

    OMIM: 182392

    KEGG: hsa:6332

    STRING: 9606.ENSP00000386796

    UniGene: Hs.596087