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RNF34 Antibody

  • 货号：
    CSB-PA856886ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA856886ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RNF34 Polyclonal antibody
  • Uniprot No.：
    Q969K3
  • 基因名：
    RNF34
  • 别名：
    CARP 1 antibody; CARP-1 antibody; CARP1 antibody; Caspase regulator CARP1 antibody; Caspases-8 and -10-associated RING finger protein 1 antibody; E3 ubiquitin-protein ligase RNF34 antibody; FYVE-RING finger protein Momo antibody; hRFI antibody; Human RING finger homologous to inhibitor of apoptosis protein antibody; RFI antibody; RIF antibody; RIFF antibody; RING finger protein 34 antibody; RING finger protein RIFF antibody; RNF34 antibody; RNF34_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF34 protein (1-220AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.
  • 基因功能参考文献：
    1. Data indicate that E3 ligase RNF34 is associated with nucleotide-binding oligomerization domain-containing protein 1 (NOD1). PMID: 25012219
    2. Data indicate AE induces caspase-8-mediated activation of mitochondrial death pathways by decreasing the stability of CARP mRNAs in a p53-independent manner. PMID: 21308745
    3. The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 was verified. PMID: 20564261
    4. a novel gene, hRFI, preferentially expressed in esophageal cancer (hRFI) PMID: 12118383
    5. hRFI may act as an oncogenic molecule affecting the apoptotic pathway PMID: 15595643
    6. CARPs together with MDM2 enhance p53 degradation, thereby inhibiting p53-mediated cell death. PMID: 18382127

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Nucleus. Nucleus speckle. Cytoplasm, cytosol.
  • 组织特异性：
    Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
  • 数据库链接：

    HGNC: 17297

    OMIM: 608299

    KEGG: hsa:80196

    STRING: 9606.ENSP00000376258

    UniGene: Hs.292804