Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. RFXAP Antibody

RFXAP Antibody

  • 货号：
    CSB-PA019618GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O00287
  • 基因名：
  • 别名：
    Regulatory factor X associated protein antibody; Regulatory factor X-associated protein antibody; RFX associated protein antibody; RFX DNA binding complex 36 kDa subunit antibody; RFX DNA-binding complex 36 kDa subunit antibody; RFX-associated protein antibody; RFXAP antibody; RFXAP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RFXAP
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Part of the RFX complex that binds to the X-box of MHC II promoters.
  • 基因功能参考文献：
    1. Data show a negative correlation between microRNA miR-212-3p and regulatory factor X-associated protein (RFXAP) in pancreatic cancer (PC) tissue. PMID: 26337469
    2. Study demonstrates that coordinate loss of MHCII expression in OCI-Ly2 DLBCL cells is associated with an 11-base deletion in the cDNA encoding RFX-AP, that is required for activating MHCII transcription. PMID: 20024540
    3. Only the C-terminal half of the protein is conserved among vertebrates. The C-terminal third of RFXAP, with an extensive glutamine-rich tract, could rescue HLA-DR, but not HLA-DQ or HLA-DP expression in a bare lymphocyte syndrome cell line. PMID: 16337482
    4. The transcriptional silent state of RFXAP correlated with reduced recruitment of RNA polymerase II to RFXAP chromatin in the MHC-II deficiency patient. PMID: 18336911
    5. the interaction between RFX5 and RFXAP promote folding of a poorly structured region ofRFXAP, which is required for high affinity binding of RFXB to the RFX5.RFXAP complex PMID: 19274739

    显示更多

    收起更多

  • 相关疾病：
    Bare lymphocyte syndrome 2 (BLS2)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 9988

    OMIM: 209920

    KEGG: hsa:5994

    STRING: 9606.ENSP00000255476

    UniGene: Hs.24422