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RB1CC1 Antibody

  • 货号：
    CSB-PA019387GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TDY2
  • 基因名：
  • 别名：
    FAK family kinase-interacting protein of 200 kDa antibody; FIP200 antibody; RB1-inducible coiled-coil protein 1 antibody; RB1CC1 antibody; RBCC1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human RB1CC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis.
  • 基因功能参考文献：
    1. RB1CC1 was shown to target ZBTB38 to initiate autophagy in spinal cord injury. PMID: 30075197
    2. These findings suggested that PHF8 played an oncogenic role in facilitating FIP200-dependent autophagic degradation of E-cadherin, EMT and metastasis in hepatocellular carcinoma (HCC). PHF8 might be a promising target for prevention, treatment and prognostic prediction of HCC. PMID: 30180906
    3. miR-224-3p regulates autophagy in hrHPV-induced cervical cancer cells through targeting FIP200 expression. PMID: 27615604
    4. Data suggest that, in patients with diabetic kidney disease, urinary excretion of mRNAs for MAP1LC3A, WIPI2, and RB1CC1 is down-regulated as compared to healthy control subjects; these transcripts may serve as urinary autophagy biomarkers. (MAP1LC3A = microtubule associated protein 1 light chain 3; WIPI2 = WD repeat domain phosphoinositide-interacting protein 2; RB1CC1 = RB1 inducible coiled-coil 1) PMID: 28760651
    5. This is the first report demonstrating that polymorphisms in the autophagy-related FIP200 gene may predict hypertension in patients with mCRC treated with FOLFIRI and bevacizumab. PMID: 28347919
    6. MiR-20a and miR-20b negatively regulate autophagy by targeting RB1CC1/FIP200 in breast cancer cells PMID: 26829385
    7. RB1CC1 has been implicated in cell cycle progression, cell growth, cell proliferation, cell survival, cell spreading/migration and neurodegeneration. PMID: 26151896
    8. miR-133b targeted and downregulated RB1CC1 in prostate cancer cells. PMID: 24610824
    9. RB1CC1 knockdown in PC3 cells enhances clonal growth in vitro and tumor growth in vivo. PMID: 24732589
    10. Liver-specific deficiency of FIP200 leads to chronic liver injury associated with fibrosis and inflammation. PMID: 23960084
    11. The APC-independent beta-catenin degradation by FIP200 suggests a role for FIP200 in tumor suppression in the presence of APC dysfunction. PMID: 22751121
    12. Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy. PMID: 23262492
    13. Nuclear expression of RB1CC1 predicts a better clinical outcome and is useful in the follow-up of salivary gland cancers. PMID: 21717524
    14. analysis of preparation of the monoclonal antibody for RB1CC1 PMID: 22396748
    15. RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism PMID: 22049074
    16. p53 regulates autophagy through a direct molecular interaction with RB1CC1/FIP200, a protein that is essential for the very apical step of autophagy initiation. PMID: 21775823
    17. RB1CC1 activates the expression of p16 (also called INK4a/CDKN2a) through the activation of its promoter. RB1CC1 essentially requires binding with hSNF5 to activate the p16 promoter. PMID: 21637919
    18. RB1CC1 thus appears to play a unique role as a modulator of TGF-beta signaling by restricting substrate specificity of Arkadia. PMID: 21795712
    19. downregulation of FIP200 protein in glioblastoma tumor cells, astrocytes, and brain microvessel endothelial cells promotes apoptosis, most likely due to the removal of a direct interaction of FIP200 with Pyk2 that inhibits Pyk2 activation PMID: 21602932
    20. RB1CC1, RB1 and p53 have prognostic roles in breast cancer in Japanese patients PMID: 21203526
    21. present study indicates that RB1CC1 together with hSNF5 and/or p53 enhances the RB1 pathway through transcriptional activation of RB1, p16 and p21 PMID: 20614030
    22. the 3'-untranslated region of RB1-inducible coiled-coil 1 gene is mutated in colon tumors PMID: 19888451
    23. RB1CC1 is frequently mutated in breast cancer and shows characteristics of a classical tumor-suppressor gene. PMID: 12068296
    24. RB1CC1 gene preferentially expressed and contributed to the maturation of human embryonic musculoskeletal cells, and may regulate the proliferative activity and maturation of tumor cells derived from these tissues. PMID: 12163359
    25. RB1CC1 induces the expression of RB1, especially of underphosphorylated forms, then suppresses cell cycle progression in human neoplastic cells PMID: 14533007
    26. expression and promoter activities of RB1CC1 in developing murine and human tissues; RB1CC1 expression is controlled more stringently by modification at intron 1 in humans than in mice PMID: 15375585
    27. FIP200 regulates of cell size by interaction with the TSC1-TSC2 complex. PMID: 16043512
    28. FIP200 increases p21 protein levels via stabilization of its upstream regulator p53 and decreases cyclin D1 protein. Both effects are critical for FIP200-induced G1 arrest and may contribute to the antitumor activities of FIP200 in breast cancer. PMID: 16061648
    29. RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases. PMID: 17706618
    30. RB1CC1 and PACE4 genes might be the DNA targets of sodium arsenite treatment in human lymphoblastoid cells. PMID: 17707572
    31. Cellular functions of FIP200 and its interacting proteins, and the emerging roles of FIP200 in embryogenesis and cancer development. Review. PMID: 18036779
    32. provide the first evidence for the existence of a close-spatially controlled-mode of regulation of FIP200 and PIASy nucleocytoplasmic functions PMID: 18285457
    33. These results suggest that FIP200 is a novel mammalian autophagy factor that functions together with ULKs. PMID: 18443221
    34. Nuclear RB1CC1 directly activates the RB1 promoter to enhance RB1 expression associated with breast cancer. PMID: 19437535
    35. Nuclear RB1CC1 directly activates the RB1 promoter to enhance RB1 expression in cancer cells. PMID: 19437535
    36. Rb1cc1 expression is a prerequisite for the induction of RB1 and myosin heavy chain. Rb1cc1 plays a crucial role in muscular differentiation and function. PMID: 15968549

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytosol. Preautophagosomal structure. Lysosome.
  • 蛋白家族：
    ATG17 family
  • 组织特异性：
    Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells.
  • 数据库链接：

    HGNC: 15574

    OMIM: 606837

    KEGG: hsa:9821

    STRING: 9606.ENSP00000025008

    UniGene: Hs.196102