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RAE1 Antibody

  • 货号：
    CSB-PA019276ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: RAE1 antibody at 4.39μg/ml
      Lane 1: Mouse brain tissue
      Lane 2: HepG2 whole cell lysate
      Lane 3: 293T whole cell lysate
      Lane 4: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 41 kDa
      Observed band size: 41, 80 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019276ESR1HU at dilution of 1: 100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA019276ESR1HU at dilution of 1: 100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RAE1 Polyclonal antibody
  • Uniprot No.：
    P78406
  • 基因名：
  • 别名：
    dJ481F12.3 antibody; dJ800J21.1 antibody; FLJ30608 antibody; Homolog of yeast Rae1 (Bharathi) mRNA associated protein of 41 kDa (Kraemer) antibody; Homolog of yeast Rae1 mRNA associated protein of 41 kDa antibody; MGC117333 antibody; MGC126076 antibody; MGC126077 antibody; MIG 14 antibody; MIG14 antibody; Migration inducing gene 14 antibody; Mnrp 41 antibody; Mnrp41 antibody; mRNA associated protein mrnp 41 antibody; mRNA binding protein 41 kD antibody; mRNA export factor antibody; mRNA export protein antibody; mRNA-associated protein mrnp 41 antibody; MRNP 41 antibody; MRNP41 antibody; RAE 1 antibody; RAE1 (RNA export 1 S.pombe) homolog antibody; rae1 antibody; RAE1 homolog antibody; Rae1 protein homolog antibody; RAE1 RNA export 1 homolog (S. pombe) antibody; RAE1 RNA export 1 homolog antibody; RAE1L_HUMAN antibody; RNA export 1 antibody; RNA export 1 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human mRNA export factor protein (1-368AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
  • 基因功能参考文献：
    1. RAE1 overexpression was associated with considerably poorer disease-free survival and distant metastasis-free survival, especially in patients with oestrogen receptor-positive tumours. PMID: 28181567
    2. show that USP11 is associated with the mitotic spindle, does not regulate SAC inactivation, but controls ubiquitination of RAE1 at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA). PMID: 29293652
    3. Nuclear export inhibition by ORF10 of human herpesvirus 8 requires an interaction with an RNA export factor, Rae1. PMID: 27832591
    4. After PSK administration, INF-g production in CD8(+) T cells increased in mice with cells expressing neither Rae-1 nor H60, but did not change in mice implanted with cells expressing both Rae-1 and H60. We demonstrated that the expression of NKG2DLs affects tumor immunity and the efficacy of immuno therapy in tumor-bearing mouse model PMID: 28739693
    5. Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 * Nup98). PMID: 24927547
    6. vesicular stomatitis virus M protein interacted efficiently with Rae1-Nup98 complexes associated with the chromatin fraction of host nuclei, consistent with an effect on host transcription PMID: 23028327
    7. mouse cytomegalovirus m152/gp40 interaction with RAE1gamma structural analysis reveals a paradigm for MHC/MHC interaction in immune evasion PMID: 23169621
    8. This study established a novel postmitotic function for rae-1 in neuronal development. PMID: 22357847
    9. RAE1 transgene orchestrates proper chromosome segregation and NUP98-mediated leukemogenesis. PMID: 21467841
    10. In a transgenic mouse model of chronic natural killer NKG2D ligand expression, constant exposure to NKG2D ligand RNA export 1 homolog (Rae-1 epsilon) does not functionally impair NK cells or CD8-positive T cells in the context of viral infection. PMID: 20530257
    11. present the crystal structure of human Rae1 in complex with the Gle2-binding sequence (GLEBS) of Nup98 at 1.65 A resolution. Rae1 forms a seven-bladed beta-propeller with several extensive surface loops. PMID: 20498086
    12. These data show an association of mrnp41 with MT and, moreover, demonstrate that an intact MT system is necessary for dispersion of mrnp41-containing particles to the cellular periphery PMID: 11831386
    13. VSV M protein blocks mRNA export by disrupting Rae1 function, which can be reverted by induction of Rae1 expression. PMID: 15629720
    14. A purified Rae1 complex stabilizes microtubules in egg extracts in a RanGTP/importin beta-regulated manner PMID: 15851029
    15. point to the Rae1-NuMA interaction as a critical element for normal spindle formation in mitosis PMID: 17172455
    16. Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation. PMID: 18212744

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    WD repeat rae1 family
  • 数据库链接：

    HGNC: 9828

    OMIM: 603343

    KEGG: hsa:8480

    STRING: 9606.ENSP00000360286

    UniGene: Hs.371698