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RAB3IP Antibody

  • 货号：
    CSB-PA853488LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA853488LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA853488LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RAB3IP Polyclonal antibody
  • Uniprot No.：
    Q96QF0
  • 基因名：
    RAB3IP
  • 别名：
    Gtpat12 antibody; Rab-3A-interacting protein antibody; RAB3A interacting protein antibody; RAB3A interacting protein (rabin3) antibody; RAB3A interacting protein antibody; RAB3A-interacting protein antibody; RAB3I_HUMAN antibody; Rab3ip antibody; Rabin 3 antibody; Rabin-3 antibody; RABIN3 antibody; RABIN3; rat; homolog of antibody; Rabin8 antibody; SSX2 interacting protein antibody; SSX2 interacting protein antibody; SSX2-interacting protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rab-3A-interacting protein (1-132AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，RAB3IP Antibody (CSB-PA853488LA01HU)，的标记方式是Non-conjugated。对于RAB3IP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA853488LB01HU RAB3IP Antibody, HRP conjugated ELISA
    FITC CSB-PA853488LC01HU RAB3IP Antibody, FITC conjugated
    Biotin CSB-PA853488LD01HU RAB3IP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
  • 基因功能参考文献：
    1. s show that Rab11-GMPPNP-FIP3-Rabin8 is more stable than Rab11-GMPPNP-Rabin8, owing to direct interaction between Rabin8 and FIP3 within the dual effector-bound complex. PMID: 26258637
    2. the role of Rabin8 (a mammalian ortholog of Sec2p) with Rab8-nucleotide-exchange factor activity in autophagy in mammalian cells, was examined. PMID: 25787272
    3. Rab11-FIP3 coordinates the interactions of ASAP1 and Rab11a with Rabin8. PMID: 25673879
    4. Rabin8 was identified as a direct phospho-substrate of ERK1/2 in response to EGF signaling. PMID: 25535387
    5. RABIN3 interacts with the cancer-related protein SSX2 and a novel nuclear protein, SSX2IP. PMID: 12007189

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    SEC2 family
  • 组织特异性：
    Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver.
  • 数据库链接：

    HGNC: 16508

    OMIM: 608686

    KEGG: hsa:117177

    STRING: 9606.ENSP00000447300

    UniGene: Hs.258209