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RAB18 Antibody

  • 货号：
    CSB-PA981899
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA981899(RAB18 Antibody) at dilution 1/300, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA981899(RAB18 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second
  • 其他：

产品详情

  • Uniprot No.：
    Q9NP72
  • 基因名：
  • 别名：
    AA959686 antibody; RAB18 antibody; RAB18 small GTPase antibody; RAB18; member RAS oncogene family antibody; RAB18_HUMAN antibody; RAB18LI1 antibody; Ras related protein Rab 18 antibody; Ras-asssociated protein RAB18 antibody; Ras-related protein Rab-18 antibody; RP11-148B2.1 antibody; WARBM3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human RAB18
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:500-1:2000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.
  • 基因功能参考文献：
    1. The s found that the previously documented interaction between TRAPPII and COPI was also required for the recruitment of Rab18 to the lipid droplet. PMID: 28003315
    2. findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people. PMID: 24996981
    3. RAB18 is the direct target of miR-455-5p in gastric cancer. PMID: 27451075
    4. Warburg Micro syndrome is caused by RAB18 deficiency. PMID: 26063829
    5. These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets. PMID: 24997429
    6. High RAB18 expression is associated with glioma. PMID: 24477653
    7. Rab18-mediated membrane trafficking of FASN and NS3 facilitates dengue virus replication. PMID: 24696471
    8. Rab18 interacts with the HCV nonstructural protein NS5A. PMID: 23935497
    9. Hepatitis B virus X protein enhances proliferation of hepatoma cells through Rab18. PMID: 23471881
    10. Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2. [Review] PMID: 23176487
    11. performed autozygosity mapping in five consanguineous families with Warburg micro syndrome without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18 PMID: 21473985
    12. Rab18 regulates lipid droplet-associated membrane formation PMID: 15914536
    13. analysis of a novel splice variant of human Rab18 gene PMID: 16147880
    14. Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion. PMID: 18349058
    15. Rab18 and Rab43 have key roles in ER-Golgi trafficking. PMID: 18664496
    16. Rab18 is recruited to lipid droplets during lipolysis PMID: 16207721

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  • 相关疾病：
    Warburg micro syndrome 3 (WARBM3)
  • 亚细胞定位：
    Apical cell membrane. Lipid droplet.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 14244

    OMIM: 602207

    KEGG: hsa:22931

    STRING: 9606.ENSP00000349415

    UniGene: Hs.406799