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  4. Phospho-PRKAB1 (Ser181) Antibody

Phospho-PRKAB1 (Ser181) Antibody

  • 中文名称：
    磷酸化-PRKAB1 (Ser181)兔多克隆抗体
  • 货号：
    CSB-PA165739
  • 规格：
    ￥2454
  • 图片：
    • Western blot analysis of extracts from Rat kindey using AMPK β1(Phospho-Ser181) Antibody.The lane on the right is treated with the antigen-specific peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PRKAB1 Polyclonal antibody
  • Uniprot No.：
    Q9Y478
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of Serine 181(L-S-S(p)-S-P) derived from Human AMPK β1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
  • 基因功能参考文献：
    1. we studied the role of the beta 1 subunit in erythrocytes and observed microcytic anemia with compensatory extramedullary hematopoiesis together with splenomegaly and increased osmotic resistance. PMID: 27666489
    2. Salicylate activates the AMP-activated protein kinase (AMPK) by binding at the A-769662 drug binding site on the AMPK beta1-subunit PMID: 25940306
    3. findings suggest that the reduced expression of AMPK-beta1 confers lower AMPK activity, which enhances the oncogenic capacity of advanced-stage ovarian cancer. PMID: 24602453
    4. The effects of ethanol on AMPK and PP2A may result in activation of ChREBP, providing another potential mechanism for ethanol-induced hepatic steatosis. PMID: 23266705
    5. Data indicate that a diet high in iron improves glucose tolerance by activating AMPK through mechanisms that include deacetylation. PMID: 23515442
    6. LKB1 controls IRS1-dependent adipogenesis via AMPK in white adipose tissue. PMID: 23396401
    7. Changes in translational control of mitochondrial proteins are signaled by the activation of AMPK and general control non-derepressible kinase 2 (GCN2), leading also to the activation of autophagy. PMID: 22435535
    8. Phosphorylation levels of AMPK and glycolysis were up-regulated to confer an advantage of survival for MERRF skin fibroblasts. PMID: 22001850
    9. Adipose tissues of markedly obese insulin resistant individuals uniformly show decreased AMPK activity and increased oxidative stress compared with insulin sensitive patients. PMID: 22323564
    10. Adiponectin could attenuate renal dysfunction associated with mesangial cells disorders through AMPK-mTOR signal pathway. PMID: 22105511
    11. 1q21.1 copy number variant (CNV) results in gene function changes, specifically in the deletion containing lymphobalst cell lines, where AMPK was attenuated. PMID: 21824431
    12. AMPK, Akt and mTOR pathways have roles in resveratrol-enhanced prostate cancer cell response to ionizing radiation PMID: 22029423
    13. cisplatin-triggered activation of AMPK and subsequent suppression of mTOR activity can induce an autophagic response that protects tumour cells from cisplatin-mediated apoptotic death PMID: 20196784
    14. LKB1-AMPK negatively regulated mTOR function in tumor. PMID: 21859551
    15. NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle PMID: 21873433
    16. Inactivation of fumarate hydratase drives a metabolic shift to aerobic glycolysis in FH-de fi cient kidney tumors resulting in decreased levels of AMP-activated kinase. PMID: 21907923
    17. Phosphorylation of AMPK by Ulk1 represents a negative feedback circuit. PMID: 21460634
    18. Androgen deprivation and hypoxia augmented AMPK activation and triggered autophagy in androgen-dependent prostate cancer cells. PMID: 21554950
    19. Glucose deprivation resulted in activation of AMPK and inhibition of Akt phosphorylation PMID: 21570709
    20. Glucose restriction or treatment of human diploid fibroblasts (HDFs) with the activators of the AMPK/p53 pathway induced the expression of IFI16 protein. PMID: 21573174
    21. results of this study show that AMPK induces MUC5B expression through the p38 MAPK signaling pathway in airway epithelial cells. PMID: 21619869
    22. The connections between AMPK and FoxO3A, are reviewed. PMID: 20190568
    23. The aim of this study was to investigate the effects of adiponectin on StAR protein expression, steroidogenic genes, and cortisol production and to dissect the signalling cascades involved in the activation of StAR expression. PMID: 21334384
    24. High AMPK expression is associated with ovarian carcinoma. PMID: 21271224
    25. AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. PMID: 20957377
    26. Endoplasmic reticulum stress triggers suppression of AMPK while increasing C/EBPbeta and pCREB expression which activates PEPCK gene transcription. PMID: 20797423
    27. There is a mutual suppressive interaction between AMPK and Akt. PMID: 21042744
    28. AMPK-mediated PLD1 activation is required for (14)C-glucose uptake through ERK stimulation PMID: 20231899
    29. The LKB1/AMPK/TSC tumor suppressor axis is functional in acute myeloid leukemia. PMID: 20668229
    30. These results suggest that the modification introduced by the laforin-malin complex could affect the subcellular distribution of AMPK beta subunits. PMID: 20534808
    31. Data suggest that AMPK is required for the serum starvation-related increase in insulin-stimulated glucose transport, with ATM as a possible downstream effector. PMID: 20810907
    32. The nuclear translocation of GAPDH might be regulated by the PI3K signaling pathway acting mainly as a nuclear export signal and the AMPK signaling pathway acting as a nuclear import signal. PMID: 20177150
    33. These observations support a role for AMPK in the regulation of Na+-coupled glucose transport. PMID: 20334581
    34. AMP-activated protein kinase inhibition mediates hepatitis C virus genome replication and lipid accumulation PMID: 20534540
    35. Data demonstrate that autophagy depends on the early activation of the AMP-activated protein kinase (AMPK)/mTOR-mediated pathway. PMID: 20083895
    36. Data showed that HDL-induced activation of AMPK is dependent on both sphingosine 1-phosphate receptors and scavenger receptor class B type I. PMID: 20018878
    37. Data suggest that upregulation of adipose triglyceride lipase and suppression of hormone-sensitive lipase and AMP kinase signaling mediate high-fat diet-induced alterations in lipolysis and lipid utilization in adipocytes. PMID: 20107043
    38. findings suggest that CCL2 hyperactivates mTORC1 through simultaneous regulation of both AMPK and Akt pathways and reveals a new network that promotes prostate cancer: CCL2-AMPK-mTORC1-survivin. PMID: 20019839
    39. Chlorophyll a up-regulated the AMPK and p-AMPK levels, and down-regulated the expression of PPAR-gamma. PMID: 19963029
    40. we will examine the evidence that AMP-activated protein kinase and SIRT1 both regulate each other and share many common target molecules--REVIEW PMID: 20103737
    41. These results indicate that AMPK activators facilitate the activation by TRAIL of an apoptotic cell death program through a mechanism independent of AMPK and dependent on the down-regulation of cFLIP levels. PMID: 19896469
    42. It is necessary to clarify the tissue-specific and stress-specific activation mechanism of AMPK--REVIEW PMID: 19911004
    43. AMPK is a novel and biologically significant participant with a tumor suppressive activity in the mitotic/cytokinetic phase of the cell cycle. PMID: 19844168
    44. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex. There is a synergistic effects of Ca2+ and AMP. PMID: 19958286
    45. Data show that AMPK activation suppressed Ox-LDL-induced macrophage proliferation by suppressing GM-CSF expression and inducing cell cycle arrest. PMID: 19843515
    46. AMP-activated protein kinase has a role in gene expression in single islet beta-cells [review] PMID: 15289653
    47. Dipyridamole, an adenosine transporter inhibitor, and 5'-amino-5'-deoxyadenosine, an adenosine kinase inhibitor, blocked the effect of AICAR on the down-regulation of the insulin receptor protein, mRNA, and promoter activity. PMID: 15694368
    48. Reduced activation of AMPK by globular adiponectin in obese and obese type 2 diabetic subjects is not caused by reduced adiponectin receptor expression. PMID: 15769985
    49. it is likely that the AMPK-GDE association is a novel mechanism regulating AMPK activity and the resultant fatty acid oxidation and glucose uptake PMID: 15886229
    50. These results suggested that the combination of 5-FU and genistein exert a novel chemotherapeutic effect in colon cancers, and AMPK may be a regulatory molecule of COX-2 expression, further implying its involvement in cytotoxicity caused by genistein. PMID: 15896711

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  • 蛋白家族：
    5'-AMP-activated protein kinase beta subunit family
  • 数据库链接：

    HGNC: 9378

    OMIM: 602740

    KEGG: hsa:5564

    STRING: 9606.ENSP00000229328

    UniGene: Hs.741184