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PTPRO Antibody

  • 货号：
    CSB-PA623099ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA623099ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA623099ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PTPRO Polyclonal antibody
  • Uniprot No.：
    Q16827
  • 基因名：
    PTPRO
  • 别名：
    FMI antibody; GLEPP 1 antibody; Glomerular epithelial protein 1 antibody; hPTP-J antibody; Pancreatic carcinoma phosphatase 2 antibody; PCP-2 antibody; PCP2 antibody; Phosphotyrosine phosphatase U2 antibody; Protein tyrosine phosphatase PTP U2 antibody; Protein tyrosine phosphatase PTPU2 antibody; Protein tyrosine phosphatase receptor type O antibody; Protein tyrosine phosphatase U2 antibody; Protein-tyrosine phosphatase J antibody; Protein-tyrosine phosphatase pi antibody; Protein-tyrosine phosphatase receptor omicron antibody; PTP pi antibody; PTP U2 antibody; PTP-J antibody; PTP-RO antibody; PTP-U2 antibody; PTPase U2 antibody; PTPRO antibody; PTPRO_HUMAN antibody; PTPROt antibody; PTPU 2 antibody; PTPU2 antibody; R-PTP-O antibody; R-PTP-psi antibody; Receptor type protein tyrosine phosphatase O antibody; Receptor type tyrosine protein phosphatase O antibody; Receptor-type protein-tyrosine phosphatase psi antibody; Receptor-type tyrosine-protein phosphatase O antibody; Receptor-type tyrosine-protein phosphatase U antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Receptor-type tyrosine-protein phosphatase O protein (30-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function.
  • 基因功能参考文献：
    1. the present study demonstrated that PTPRO inhibits tumor growth in vitro and in vivo, indicating the tumor suppressive function of PTPRO in LSCC. This study highlights PTPRO as an epigenetically silenced gene, and a candidate tumor-suppressor of LSCC. PMID: 28586036
    2. Single nucleotide polymorphism in PTPRO gene is associated with Acute Renal Graft Rejection. PMID: 27272414
    3. Results provide evidence that PTPRO inhibits ERBB2-driven breast cancer through dephosphorylation leading to dual effects of ERBB2 signaling suppression and endosomal internalization of ERBB2. PMID: 27345410
    4. PTPRO is a novel candidate gene in emphysema with severe airflow obstruction. PMID: 28199135
    5. PTPRO truncated serves as an important tumor suppressor in hepatocellular carcinoma microenvironment. PMID: 26117839
    6. These observations confirm that PTPRO plays a critical role in liver fibrogenesis by affecting PDGF signaling in HSC activation and might be developed into a feasible therapeutic approach for the treatment of chronic fibrotic liver diseases. PMID: 25633279
    7. The optimal pH value of PTP-oc is approximately 7.0. PMID: 25462809
    8. Loss of PTPRO expression is associated with chronic lymphocytic leukemia. PMID: 25482129
    9. Results highlight the PTPRO contribution in negative regulation of SRC/EGFR signaling in colon cancer. PMID: 25301722
    10. PTPRO was drastically decreased in fulminant hepatitis, and this was associated with enhanced beta-catenin accumulation but reduced IFN-gamma secretion. PMID: 25339662
    11. Our study suggests an interesting PTPRO/TLR4/NF-kappaB signaling feedback loop in Hhepatocellular carcinomcarcinogenesis and progression PMID: 25034527
    12. PTPRO level was decreased in the early phase but reversed in the late phase of hepatic ischemia reperfusion injury. PMID: 24128416
    13. PTPRO methylation is associated with poor survival only in HER2-positive patients. PMID: 24090193
    14. methylation and downregulation of PTPRO in a subset of primary human HCC and establish VCP as a novel functionally important substrate of this tyrosine phosphatase that could be a potential molecular target for HCC therapy. PMID: 23533167
    15. ErbB2 is a direct substrate of PTPRO and decreased expression of PTPRO predicts poor prognosis for ErbB2-positive breast cancer patients. PMID: 22851698
    16. Three intronic SNPs in PTPRO were associated with learning and memory. PMID: 22126837
    17. hypermethylated PTPRO occurs frequently in esophageal squamous cell carcinoma PMID: 22099875
    18. These findings further substantiate the role of TCL1 in PTPROt suppression and its importance in the pathogenesis of chronic lymphocytic leukemia. PMID: 22001392
    19. The present study introduces mutations in PTPRO as another cause of autosomal-recessive nephrotic syndrome. PMID: 21722858
    20. conclude that an intronic promoter within the protein tyrosine phosphatase, receptor type(GLEPP1) gene drives the expression of the protein tyrosine phosphatase-osteoclast(PTP) in a cell type-specific manner PMID: 12949066
    21. Growth-suppressor characteristics of PTPRO are unique to a classical tumor suppressor in lung cancer. PMID: 15356345
    22. overexpression of PTPROt inhibited BCR-triggered SYK tyrosyl phosphorylation, activation of the associated adaptor proteins SHC and BLNK, and downstream signaling events, and inhibition lymphoma cell proliferation and inducion of lymphoma cell apoptosis PMID: 16888096
    23. PTPRO methylation and silencing has a role in chronic lymphocytic leukemia tumorigenesis PMID: 17545520
    24. GLEPP1 expression may be a useful marker of podocyte injury in immunoglobulin A nephropathy, and may be predictive of clinical and pathological severity PMID: 17593862
    25. PTPRO gene is co-regulated by both E2F1 and miR-17-92. PMID: 18644370
    26. These data suggest that estrogen-mediated suppression of PTPRO is probably one of the early events in estrogen-induced tumorigenesis and that expression of PTPRO could facilitate endocrine therapy of breast cancer. PMID: 19095770
    27. Dimerization of neuronal type III receptor-protein tyrosine phosphatase PTPRO in living cells is regulated by disulfide linkages in the PTPRO intracellular domain. PMID: 19573017
    28. BCL6 repressed PTPROt transcription via a direct interaction with functional BCL6 binding sites in the PTPROt promoter PMID: 19855081

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  • 相关疾病：
    Nephrotic syndrome 6 (NPHS6)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 3 subfamily
  • 组织特异性：
    Glomerulus of kidney. Also detected in brain, lung and placenta.
  • 数据库链接：

    HGNC: 9678

    OMIM: 600579

    KEGG: hsa:5800

    STRING: 9606.ENSP00000281171

    UniGene: Hs.160871