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PTPRN2 Antibody

  • 货号：
    CSB-PA040114
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q92932
  • 基因名：
    PTPRN2
  • 别名：
    IA 2beta antibody; IA2beta antibody; IAR antibody; IAR/receptor like protein tyrosine phosphatase antibody; ICAAR antibody; Islet cell autoantigen related protein antibody; Islet cell autoantigen-related protein antibody; Phogrin antibody; Protein tyrosine phosphatase receptor pi antibody; Protein tyrosine phosphatase, receptor type, N polypeptide 2 antibody; PTPR2_HUMAN antibody; Ptprn2 antibody; PTPRP antibody; R PTP N2 antibody; R-PTP-N2 antibody; Receptor-type tyrosine-protein phosphatase N2 antibody; Tyrosine phosphatase IA 2 beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PTP IA-2β.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization. Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate. Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments.
  • 基因功能参考文献：
    1. Copy-number variations are enriched for PTPRN2 and other neurodevelopmental genes in children with developmental coordination disorder. PMID: 27489308
    2. Haplotype-dependent allele-specific methylation of PTPRN2 gene is associated with neurological disorders. PMID: 27153397
    3. Reduction in plasma membrane PI(4,5)P2 abundance by PTPRN2 and PLCbeta1 releases the PI(4,5)P2-binding protein cofilin from its inactive membrane-associated state into the cytoplasm where it mediates actin turnover dynamics. PMID: 26620550
    4. Data indicate the X-ray structure of the mature ectodomain of mature ectodomain of phogrin/IA-2beta (PTPRN2) (ME phogrin) at pH 7.4 and 4.6. PMID: 25421040
    5. ProPTPRN2 elicited these effects through direct interaction with TRAF2. PMID: 25877877
    6. While PTPRN2 shares sequence similarity with protein tyrosine phosphatases, this study in rat suggests that this protein instead functions as a membrane bound phosphatidylinositol phosphatase. PMID: 20097759
    7. The findings in this patient raise the possibility that PTPRN2 may be active during early development of the human brainstem and that its overexpression may cause bilateral Duane retraction syndrome as occurs in patients with homozygous HOXA1 mutations. PMID: 22950449
    8. IA-2beta is involved in insulin secretion, but despite its importance as a major autoantigen in human type 1 diabetes, it is not required for the development of diabetes in NOD mice. PMID: 15220191
    9. In mice IA-2beta expressed exclusively in dense core secretory vesicles (DCV) and with fractions rich in synaptic vesicles (SV) of neuroendocrine cells of brain and impairment of conditioned learning. PMID: 19361477

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  • 相关疾病：
    Autoantigen in insulin-dependent diabetes mellitus (IDDM).
  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein.; [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 8 subfamily
  • 组织特异性：
    Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.
  • 数据库链接：

    HGNC: 9677

    OMIM: 601698

    KEGG: hsa:5799

    STRING: 9606.ENSP00000374069

    UniGene: Hs.490789