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PTPN4 Antibody

  • 货号：
    CSB-PA019041GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P29074
  • 基因名：
    PTPN4
  • 别名：
    MEG antibody; megakaryocyte phosphatase antibody; megakaryocyte protein-tyrosine phosphatase antibody; Protein tyrosine phosphatase MEG1 antibody; Protein tyrosine phosphatase; megakaryocyte antibody; protein tyrosine phosphatase; non-receptor type 4 (megakaryocyte) antibody; Protein-tyrosine phosphatase MEG1 antibody; PTN4 antibody; PTN4_HUMAN antibody; PTPase MEG1 antibody; PTPase-MEG1 antibody; PTPMEG antibody; PTPMEG1 antibody; Ptpn4 antibody; Tyrosine protein phosphatase non receptor type 4 antibody; Tyrosine-protein phosphatase non-receptor type 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PTPN4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton.
  • 基因功能参考文献：
    1. Binding assays confirmed that three (Cyto8-mtxd-1, Cyto8-mtxk-4 and Cyto8-mtxd-1k-4) out of the five designed peptides exhibit moderately or considerably increased affinity as compared to the native peptide Cyto8-RETEV PMID: 27923202
    2. the p38gamma.PTPN4 interaction promotes cellular signaling, preventing cell death induction. PMID: 27246854
    3. Deletion of PTPN4 has been reported in monozygotic twins with a Rett syndrome-like phenotype. PMID: 25424712
    4. The physiologically active PTPN4 two-domain (the PDZ and the phosphatase domains) adopts a predominant compact conformation in solution. PDZ ligand binding restores the catalytic competence of PTPN4 disrupting the transient interdomain communication. PMID: 25158884
    5. These findings suggest that PTPN4 negatively regulates cell proliferation and motility through dephosphorylation of CrkI. PMID: 23666597
    6. PTPN4 is dispensable for T cell development and/or T cell effector functions. PMID: 18614237

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 数据库链接：

    HGNC: 9656

    OMIM: 176878

    KEGG: hsa:5775

    STRING: 9606.ENSP00000263708

    UniGene: Hs.469809